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Acute norovirus‐induced agranulocytosis in a pediatric kidney transplant recipient

Norovirus (NoV) infection is usually limited to the gastrointestinal (GI) tract. However, in immunocompromised patients, this infection might lead to severe life‐threatening complications. We herein describe a pediatric kidney transplant patient who presented with an acute NoV infection complicated...

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Published in:	Transplant infectious disease 2012-08, Vol.14 (4), p.E27-E29
Main Authors:	Chehade, H., Girardin, E., Delich, V., Pascual, M.‐A., Venetz, J.‐P., Cachat, F.
Format:	Article
Language:	English
Subjects:	Acute Disease agranulocytosis Agranulocytosis - virology Caliciviridae Infections - complications Caliciviridae Infections - virology Child Differential diagnosis Female Gastrointestinal tract Humans Immunocompromised Host Immunocompromised hosts immunosuppression Infection kidney Kidney transplantation Kidney Transplantation - adverse effects Neutropenia Norovirus Norovirus - pathogenicity pediatric Pediatrics renal transplant
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container_title	Transplant infectious disease
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creator	Chehade, H. Girardin, E. Delich, V. Pascual, M.‐A. Venetz, J.‐P. Cachat, F.
description	Norovirus (NoV) infection is usually limited to the gastrointestinal (GI) tract. However, in immunocompromised patients, this infection might lead to severe life‐threatening complications. We herein describe a pediatric kidney transplant patient who presented with an acute NoV infection complicated by febrile agranulocytosis that resolved with improvement of her GI illness. This unusual presentation has not been described before, to our knowledge. The aim of this article is to highlight the sometimes dramatic clinical presentation of NoV infection in immunosuppressed patients, and the importance of including this infection in the differential diagnosis of neutropenia in that specific population.
doi_str_mv	10.1111/j.1399-3062.2012.00754.x
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However, in immunocompromised patients, this infection might lead to severe life‐threatening complications. We herein describe a pediatric kidney transplant patient who presented with an acute NoV infection complicated by febrile agranulocytosis that resolved with improvement of her GI illness. This unusual presentation has not been described before, to our knowledge. The aim of this article is to highlight the sometimes dramatic clinical presentation of NoV infection in immunosuppressed patients, and the importance of including this infection in the differential diagnosis of neutropenia in that specific population.</abstract><cop>Denmark</cop><pmid>22676808</pmid><doi>10.1111/j.1399-3062.2012.00754.x</doi><tpages>3</tpages></addata></record>
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subjects	Acute Disease agranulocytosis Agranulocytosis - virology Caliciviridae Infections - complications Caliciviridae Infections - virology Child Differential diagnosis Female Gastrointestinal tract Humans Immunocompromised Host Immunocompromised hosts immunosuppression Infection kidney Kidney transplantation Kidney Transplantation - adverse effects Neutropenia Norovirus Norovirus - pathogenicity pediatric Pediatrics renal transplant
title	Acute norovirus‐induced agranulocytosis in a pediatric kidney transplant recipient
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