Sleep stage II contributes to the consolidation of declarative memories

• Published in: Neuropsychologia 2012-08, Vol.50 (10), p.2389-2396
• Main Authors: Ruch, Simon, Markes, Oliver, Duss, Simone B., Oppliger, Daniel, Reber, Thomas P., Koenig, Thomas, Mathis, Johannes, Roth, Corinne, Henke, Katharina
• Format: Article
• Language: English
• Subjects: Adult; Adult and adolescent clinical studies; Association; Biological and medical sciences; Delta Rhythm - physiology; Delta waves; Explicit; Humans; Implicit; Learning; Learning - physiology; Male; Medical sciences; Memory; Memory - physiology; Mental Recall - physiology; Nap; Neuropsychological Tests; Organic mental disorders. Neuropsychology; Oscillations; Polysomnography - instrumentation; Polysomnography - methods; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Recall; Sleep (NREM); Sleep Stages - physiology; Slow oscillations; Spindles; Time Factors; Waves; Young Adult
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2012.06.008

Various studies suggest that non-rapid eye movement (NREM) sleep, especially slow-wave sleep (SWS), is vital to the consolidation of declarative memories. However, sleep stage 2 (S2), which is the other NREM sleep stage besides SWS, has gained only little attention. The current study investigated whether S2 during an afternoon nap contributes to the consolidation of declarative memories. Participants learned associations between faces and cities prior to a brief nap. A cued recall test was administered before and following the nap. Spindle, delta and slow oscillation activity was recorded during S2 in the nap following learning and in a control nap. Increases in spindle activity, delta activity, and slow oscillation activity in S2 in the nap following learning compared to the control nap were associated with enhanced retention of face-city associations. Furthermore, spindles tended to occur more frequently during up-states than down-states within slow oscillations during S2 following learning versus S2 of the control nap. These findings suggest that spindles, delta waves, and slow oscillations might promote memory consolidation not only during SWS, as shown earlier, but also during S2. ► We analyzed the effect of NREM sleep II (S2) on the retention of declarative memories. ► Sleep parameters of S2 were compared between a nap following learning and a control nap. ► S2 spindle, delta and slow oscillation activity correlated with across-sleep memory retention. ► Spindles were redistributed from down- to up-states of S2 slow oscillations following learning. ► The contribution of S2 to memory retention appears independent of slow-wave sleep.