Oxidative stress in the airways of children with asthma and allergic rhinitis

• Published in: Pediatric allergy and immunology 2012-09, Vol.23 (6), p.556-561
• Main Authors: Celik, Melda, Tuncer, Ayfer, Soyer, Ozge U., Saçkesen, Cansın, Tanju Besler, H, Kalayci, Omer
• Format: Article
• Language: English
• Subjects: Adolescent; Airway management; Allergic rhinitis; Allergies; antioxidant; Antioxidants; Asthma; Asthma - metabolism; Biological and medical sciences; Biomarkers - analysis; Breath Tests; Child; Children; Children & youth; Chromatography, High Pressure Liquid; Chronic obstructive pulmonary disease, asthma; Condensates; exhaled breath condensate; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; Glutathione; Glutathione - analysis; High-performance liquid chromatography; Humans; Hypersensitivity; Male; Malondialdehyde; Malondialdehyde - analysis; Medical sciences; Oxidants; Oxidative Stress; Pediatrics; Pneumology; reactive oxygen species; Respiratory tract; Rhinitis, Allergic; Rhinitis, Allergic, Perennial - metabolism; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
• ISSN: 0905-6157; 1399-3038
• DOI: 10.1111/j.1399-3038.2012.01294.x

To cite this article: Celik M, Tuncer A, Soyer OU, Saçkesen C, Tanju Besler H, Kalayci O. Oxidative stress in the airways of children with asthma and allergic rhinitis. Pediatric Allergy Immunology 2012: 23: 556–561. Introduction:  Even though it is well known that oxidant stress plays an important role in the pathogenesis of asthma, less is known about allergic rhinitis. Moreover, it is not known whether the co‐existence of the two diseases augments the level of oxidant stress within a united airway concept. Aim:  To define the level of oxidative stress in children with asthma and/or allergic rhinitis in nasal and oral exhaled breath condensates (EBC) of children. Method:  Children aged 6–18 years with asthma (n = 28), allergic rhinitis (n = 17), asthma and allergic rhinitis (n = 100), and healthy controls (n = 74) were enrolled in the study. Levels of malondialdehyde (MDA) as a marker of oxidative stress and reduced glutathione (GSH) as an antioxidant were measured by High‐Performance Liquid Chromatography in the EBC. Results:  Malondialdehyde levels were higher, and GSH levels were lower in all patient groups compared to healthy controls in both nasal and oral EBC samples (p