Evolution of highly pathogenic avian influenza (H5N1) virus populations in Vietnam between 2007 and 2010

Abstract We report on the genetic analysis of 213 highly pathogenic avian influenza (HPAI) H5N1 viruses isolated from poultry in Vietnam between 2007 and 2010. Phylogenetic analyses of the viral genomes revealed 38 distinct viral genotypes, 29 were novel and 9 were reported in Vietnam or neighboring...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2012-10, Vol.432 (2), p.405-416
Main Authors: Nguyen, Tung, Rivailler, Pierre, Davis, C. Todd, Thi Hoa, Do, Balish, Amanda, Hoang Dang, Nguyen, Jones, Joyce, Thi Vui, Dam, Simpson, Natosha, Thu Huong, Ngo, Shu, Bo, Loughlin, Rosette, Ferdinand, Karen, Lindstrom, Stephen E, York, Ian A, Klimov, Alexander, Donis, Ruben O
Format: Article
Language:English
Subjects:
Animals
Chickens - virology
Disease Outbreaks
Drift
Ducks - virology
Evolution
Evolution, Molecular
Fitness
Fowl plague
Genetic analysis
Genomes
Genotype
Genotypes
Geographic distribution
H5N1
Hemagglutinin Glycoproteins, Influenza Virus - genetics
Highly pathogenic avian influenza virus
Humans
Infection
Infectious Disease
Influenza A Virus, H5N1 Subtype - genetics
Influenza A Virus, H5N1 Subtype - isolation & purification
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza in Birds - epidemiology
Influenza in Birds - virology
Influenza, Human - epidemiology
Orthomyxovirus
Phylogenetics
Phylogeny
Poultry
Poultry Diseases - epidemiology
Poultry Diseases - virology
Prevalence
Reassortant Viruses - genetics
Reassortment
Vietnam - epidemiology
Zoonoses - epidemiology
Zoonoses - virology
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Summary:Abstract We report on the genetic analysis of 213 highly pathogenic avian influenza (HPAI) H5N1 viruses isolated from poultry in Vietnam between 2007 and 2010. Phylogenetic analyses of the viral genomes revealed 38 distinct viral genotypes, 29 were novel and 9 were reported in Vietnam or neighboring countries in recent years. Viruses from only six genotypes persisted beyond one season or year. Thus, most reassortant viruses were transient, suggesting that such genotypes lacked significant fitness advantages. Viruses with clade 2.3.2.1 HA were re-introduced into Vietnam in 2009 and their prevalence rose steeply towards the end of 2010. Clade 2.3.4-like viruses (genotype V) were predominant in northern Vietnam and caused the majority of zoonotic infections, whereas clade 1.1 (genotype Z) viruses were only detected in the Mekong delta region, in southern Vietnam. Antigenic analysis of representative viruses from the four clades indicated substantial drift.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2012.06.021