Sinonasal aspergillosis in dogs: a review

Sinonasal aspergillosis is an uncommon, yet debilitating and often frustrating condition to treat in dogs despite years of research evaluating pathogenesis, diagnosis and treatment. The disease is most commonly caused by non‐invasive fungal infection, thought to be secondary to altered innate and/or...

Full description

Saved in:
Bibliographic Details
Published in:Journal of small animal practice 2012-08, Vol.53 (8), p.434-444
Main Authors: Sharman, M. J., Mansfield, C. S.
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - therapeutic use
Aspergillosis
Aspergillosis - diagnosis
Aspergillosis - microbiology
Aspergillosis - prevention & control
Aspergillosis - veterinary
Aspergillus
Aspergillus fumigatus - isolation & purification
Aspergillus fumigatus - pathogenicity
Dog Diseases - diagnosis
Dog Diseases - microbiology
Dog Diseases - prevention & control
Dogs
Immune response
Infection
Nose Diseases - veterinary
Reviews
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sinonasal aspergillosis is an uncommon, yet debilitating and often frustrating condition to treat in dogs despite years of research evaluating pathogenesis, diagnosis and treatment. The disease is most commonly caused by non‐invasive fungal infection, thought to be secondary to altered innate and/or adaptive immune responses. Attempts to confirm this have however failed. A variety of conflicting opinions regarding the diagnosis and treatment of sinonasal aspergillosis exist. Often the use of a particular treatment protocol is based upon personal or regional preference. Evaluation of the veterinary literature demonstrates that the evidence base in support of individual treatment recommendations is weak. A number of recent publications have helped to expand the current knowledge base and therefore our understanding of important practicalities for both diagnostic options and treatment protocols. The following review examines the current evidence for the pathogenesis of sinonasal aspergillosis in dogs, as well as the various diagnostic options. The available evidence for frequently utilised ‐therapeutic options and their likely outcomes is also explored.
ISSN:0022-4510
1748-5827
DOI:10.1111/j.1748-5827.2012.01245.x