Aspergillus nidulans and Chronic Granulomatous Disease: A Unique Host-Pathogen Interaction

Invasive fungal infections are a major threat for patients suffering from chronic granulomatous disease (CGD), a primary immunodeficiency caused by a defect in the nicotinamide adenine dinudeotide phosphate (NADPH) -oxidase. Interestingly, Aspergillus (Etnericella) nidulans is the second most encoun...

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Bibliographic Details
Published in:The Journal of infectious diseases 2012-10, Vol.206 (7), p.1128-1137
Main Authors: Henriet, Stefanie S. V., Verweij, Paul E., Warris, Adilia
Format: Article
Language:English
Subjects:
Animals
Antifungals
Aspergillosis - enzymology
Aspergillosis - immunology
Aspergillosis - microbiology
Aspergillus
Aspergillus nidulans
Aspergillus nidulans - physiology
Biological and medical sciences
Chronic granulomatous disease
Conidia
Fundamental and applied biological sciences. Psychology
Fungal infections
FUNGI
Granulomatous Disease, Chronic - complications
Granulomatous Disease, Chronic - enzymology
Granulomatous Disease, Chronic - immunology
Host-Pathogen Interactions
Humans
Immunity, Innate
Infections
Infectious diseases
Macrophages, Alveolar - enzymology
Macrophages, Alveolar - immunology
Macrophages, Alveolar - microbiology
Medical sciences
Mice
Microbiology
Miscellaneous
Mycology
NADPH Oxidases - metabolism
Neutrophils
Neutrophils - immunology
Neutrophils - microbiology
Pathogens
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Description
Summary:Invasive fungal infections are a major threat for patients suffering from chronic granulomatous disease (CGD), a primary immunodeficiency caused by a defect in the nicotinamide adenine dinudeotide phosphate (NADPH) -oxidase. Interestingly, Aspergillus (Etnericella) nidulans is the second most encountered mold in CGD patients, causing almost exclusively invasive infections in this specific host, and is characterized by its aggressive behavior. A proper diagnosis is complicated by the often mild clinical presentation, the low sensitivity of the currently used diagnostic tools, and the difficulties in accurate identification of the Emericella species. According to the hitherto accepted view on the role of the NADPH-oxidase in the innate hostdefense pathway, the pathogenesis of A. nidulans in CGD cannot be explained. This synopsis covers the current understanding of invasive infections caused by A. nidulans in the CGD patient and is intended to direct further research by indicating gaps in our knowledge and to guide optimal management strategies.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jis473