The protective and healing effects of Si Shen Wan in trinitrobenzene sulphonic acid-induced colitis

Si Shen Wan is a traditional Chinese herbal medicine formula for the treatment of diseases with diarrhea, such as ulcerative colitis, allergic colitis and chronic colitis. To investigate the protective and healing effects of Si Shen Wan in the experimental colitis induced by trinitrobenzene sulphoni...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2012-09, Vol.143 (2), p.435-440
Main Authors: Liu, Duan-yong, Guan, Yong-mei, Zhao, Hai-mei, Yan, Dong-mei, Tong, Wen-ting, Wan, Pan-ting, Zhu, Wei-feng, Liu, Hong-ning, Liang, Xin-li
Format: Article
Language:English
Subjects:
Animals
Colitis
Colitis - chemically induced
Colitis - drug therapy
Colitis - metabolism
Colitis - pathology
colon
diarrhea
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Female
gene expression
glutathione peroxidase
Glutathione Peroxidase - metabolism
Inflammatory activities
interleukin-10
Interleukin-10 - genetics
interleukin-4
Interleukin-4 - genetics
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Intestinal Mucosa - pathology
Male
Malondialdehyde - metabolism
mechanism of action
messenger RNA
mucosa
Oxidizing reaction
Peroxidase - metabolism
Phytotherapy
Protective Agents - pharmacology
Protective Agents - therapeutic use
protective effect
Rats
Rats, Sprague-Dawley
RNA, Messenger - metabolism
Si Shen Wan
silicon
sulfonic acid
superoxide dismutase
Superoxide Dismutase - metabolism
Trinitrobenzenesulfonic Acid
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Summary:Si Shen Wan is a traditional Chinese herbal medicine formula for the treatment of diseases with diarrhea, such as ulcerative colitis, allergic colitis and chronic colitis. To investigate the protective and healing effects of Si Shen Wan in the experimental colitis induced by trinitrobenzene sulphonic acid, and to furture explore its mechanism of action. Rats with colitis treated with Si Shen Wan for 10 days. Colon wet weight, colon organ coefficient, colonic damage score and pathological change after trinitrobenzene sulphonic acid challenge were determined. The levels of MPO, MDA, GSH-PX, SOD and the expression of IL-4 and IL-10 mRNA in the colon were also measured. After treatment, colon wet weight, colon organ coefficient and colonic damage score were lower than that in the control group (p
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2012.05.060