Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

• Published in: Clinical biochemistry 2012-09, Vol.45 (13-14), p.1075-1080
• Main Authors: Suk, Ki Tae, Kim, Dong Joon, Kim, Chang Hoon, Park, Seung Ha, Cheong, Jae Youn, Cho, Sung Won, Choi, Jong Young, Han, Kwang Hyub, Sung, Ho Taik, Hong, So Hyung, Kim, Dae Yong, Yoon, Jai Hoon, Kim, Yeon Soo, Baik, Gwang Ho, Kim, Jin Bong
• Format: Article
• Language: English
• Subjects: Adult; Apolipoprotein A-I - blood; Area Under Curve; Biological and medical sciences; Biological markers; Biomarkers - blood; Biomarkers - chemistry; Biopsy, Fine-Needle; Diagnosis; Extracellular matrix; Female; Gastroenterology. Liver. Pancreas. Abdomen; Haptoglobins - analysis; Hepacivirus - pathogenicity; Hepatic veins; Hepatic Veins - chemistry; Hepatitis B virus - pathogenicity; Hepatitis B, Chronic - pathology; Hepatitis B, Chronic - virology; Hepatitis C, Chronic - pathology; Hepatitis C, Chronic - virology; Human viral diseases; Humans; Infectious diseases; Investigative techniques, diagnostic techniques (general aspects); Liver Cirrhosis - diagnosis; Liver Cirrhosis - virology; Liver fibrosis; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Logistic Models; Male; Matrix Metalloproteinase 2 - blood; Medical sciences; Middle Aged; Other diseases. Semiology; Peptide Fragments - blood; Predictive Value of Tests; Procollagen - blood; Prospective Studies; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Tissue Inhibitor of Metalloproteinase-1 - blood; Viral diseases; Viral hepatitis
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2012.04.031

The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Patients with chronic viral hepatitis (n=101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV–PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (−3.13+0.017×MMP2−0.019×haptoglobin and −0.270+0.007×HA−0.018×haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p=0.03), MMP2 (0.72/0.63, p=0.04), HA (0.79/0.76, p=0.94), Apo-A1 (0.56/0.48, p=0.73), and predictive logit-model (0.81/0.78, p=0.68) showed higher diagnostic value in the HV sample. While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis. ► Biomarkers measured in the PV are insufficient to evaluate advanced fibrosis. ► HVPG is a good diagnostic modality compared to serologic biomarkers. ► Development of liver-specific serological marker is necessary.