Control of MicroRNA Expression as a New Way for Resveratrol To Deliver Its Beneficial Effects

• Published in: Journal of agricultural and food chemistry 2012-09, Vol.60 (36), p.8783-8789
• Main Authors: Lançon, Allan, Kaminski, Jacques, Tili, Esmerina, Michaille, Jean-Jacques, Latruffe, Norbert
• Format: Article
• Language: English
• Subjects: Animals; anti-inflammatory activity; Biological and medical sciences; Fermented food industries; Food industries; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - drug effects; grapes; human cell lines; Humans; inflammation; metabolism; microRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Plant Extracts - pharmacology; polyphenols; pulp; resveratrol; seeds; Stilbenes - pharmacology; Vitis - chemistry; wines; Wines and vinegars
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf301479v

Grapes produce large amounts of polyphenols. Many of them accumulate in the skin, pulp, and seeds and are consequently found in wine. The health benefits of a moderate consumption of wine have been attributed at least in part to grape’s polyphenols. Among them, resveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin that stimulates plant cell defenses against infections and also plays protective roles in humans, where it delays cardiovascular alterations and exerts anticancer and anti-inflammatory effects. Despite numerous studies, the molecular mechanisms of resveratrol action are only partially understood. Given its pleiotropic effects, it was previously suggested that resveratrol protective properties may arise from its modulation of the expression of microRNAs. Therefore, this review will focus on the effects of resveratrol on microRNA populations in humans and human cell lines, especially emphasizing the microRNAs that have been implicated in resveratrol effects on inflammation, cancer, metabolism, and muscle differentiation