Multifunctional Hybrid Nanoconjugates for Efficient In Vivo Delivery of Immunomodulating Oligonucleotides and Enhanced Antitumor Immunity

A winning combination: Multifunctional hybrid nanoconjugates (HNCs) based on polymer nanoparticles containing quantum dots (QDs) conjugated with CpG oligonucleotides (as a ligand for TLR9) and STAT3 siRNAs (to suppress the immune response) have been synthesized (see scheme). These HNCs were shown to...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-09, Vol.51 (38), p.9670-9673
Main Authors: Kim, Ji Hyun, Noh, Young-Woock, Heo, Min Beom, Cho, Mi Young, Lim, Yong Taik
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - immunology
Antineoplastic Agents - pharmacology
antitumor agents
dendritic cells
Dendritic Cells - drug effects
Dendritic Cells - immunology
drug delivery
Drug Delivery Systems
fluorescent probes
Humans
hybrid nanoconjugates
Immunomodulation
Mice
Nanoconjugates - administration & dosage
Nanoconjugates - chemistry
Neoplasms - drug therapy
Neoplasms - immunology
Oligonucleotides - administration & dosage
Oligonucleotides - immunology
Oligonucleotides - pharmacology
Quantum Dots
RNA, Messenger - drug effects
RNA, Messenger - genetics
RNA, Messenger - immunology
RNA, Small Interfering - chemistry
RNA, Small Interfering - genetics
RNA, Small Interfering - immunology
STAT3 Transcription Factor - antagonists & inhibitors
STAT3 Transcription Factor - genetics
STAT3 Transcription Factor - immunology
Structure-Activity Relationship
Toll-Like Receptors - agonists
Toll-Like Receptors - immunology
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Description
Summary:A winning combination: Multifunctional hybrid nanoconjugates (HNCs) based on polymer nanoparticles containing quantum dots (QDs) conjugated with CpG oligonucleotides (as a ligand for TLR9) and STAT3 siRNAs (to suppress the immune response) have been synthesized (see scheme). These HNCs were shown to synergistically enhance the antitumor immune response in dendritic cells and in tumor‐bearing mice.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201204989