Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted...

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Published in:Toxicologic pathology 2012-08, Vol.40 (6_suppl), p.40S-121S
Main Authors: Creasy, Dianne, Bube, Axel, Rijk, Eveline de, Kandori, Hitoshi, Kuwahara, Maki, Masson, Regis, Nolte, Thomas, Reams, Rachel, Regan, Karen, Rehm, Sabine, Rogerson, Petrina, Whitney, Katharine
Format: Article
Language:English
Subjects:
Animals
Animals, Laboratory
Biomedical Research - standards
Genital Diseases, Male - classification
Genital Diseases, Male - pathology
Genitalia, Male - chemistry
Genitalia, Male - cytology
Genitalia, Male - pathology
Histocytochemistry
Male
Mice
Rats
Terminology as Topic
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Summary:The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623312454337