Impact of Catastrophic Brain Injury Guidelines on Donor Management Goals at a Level I Trauma Center

• Published in: Transplantation proceedings 2012-09, Vol.44 (7), p.2190-2192
• Main Authors: Quinn, L, McTague, W, Orlowski, J.P
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Brain Injuries - physiopathology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Medical sciences; Practice Guidelines as Topic; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue Donors; Tissue, organ and graft immunology; Trauma Centers
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2012.07.112

Abstract Background An organ procurement organization (OPO) and a level I trauma center developed catastrophic brain injury guidelines (CBIGs) to assist in the care of severely brain-injured adult patients before brain death. The CBIGs provided a set of clinical guidelines to maintain patient stability and optimize opportunity for organ donation. Objective The aim of this study was to determine if the use of the CBIGs affected the OPO's ability to achieve donor management goals (DMGs) before organ recovery. Methods We conducted a retrospective analysis comparing the number of DMGs met in the hospital's donors before and after the CBIGs were used. The analysis included 133 cases; 67 donors in the pre-CBIG data and 66 donors in the post-CBIG review. Donor management goals measured included: systolic blood pressure >100 mm Hg; 1 pressor ≤10 μg/kg/min; urine output 1–2 mL/kg/h; pO2 >100 mm Hg; Na