Effects of Physicochemical Forms of Phenazepam and Panavir on Their Action at Ultra-Low Doses

A concept of physicochemical forms of biologically active substances introduced in investigation of the action mechanism of ultra-low doses allows qualitative explanation of the main effects of ultra-low doses, chemical diversity of biologically active substances, and physical boundaries for these e...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-08, Vol.153 (4), p.455-458
Main Authors: Stovbun, S. V., Kiselev, A. V., Zanin, A. M., Kalinina, T. S., Voronina, T. A., Mikhailov, A. I., Berlin, A. A.
Format: Article
Language:English
Subjects:
Animals
Benzodiazepines - chemistry
Benzodiazepines - pharmacology
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Cell Biology
Dose-Response Relationship, Drug
Internal Medicine
Laboratory Medicine
Micelles
Nanoparticles - chemistry
Pathology
Peritonitis - drug therapy
Probucol - chemistry
Probucol - pharmacology
Rats
Surface-Active Agents - chemistry
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Summary:A concept of physicochemical forms of biologically active substances introduced in investigation of the action mechanism of ultra-low doses allows qualitative explanation of the main effects of ultra-low doses, chemical diversity of biologically active substances, and physical boundaries for these effects. Phenazepam was shown to possess activity in ultra-low doses only in disperse state, in the form of nanoparticles with a diameter
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1739-z