IDH1 Mutations Disrupt Blood, Brain, and Barriers

The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collage...

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Bibliographic Details
Published in:Cancer cell 2012-09, Vol.22 (3), p.285-287
Main Authors: Shih, Alan H., Levine, Ross L.
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Cell Transformation, Neoplastic
Epigenesis, Genetic
Hematopoiesis
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - physiology
Hematopoietic System - physiology
Isocitrate Dehydrogenase - genetics
Isocitrate Dehydrogenase - metabolism
Mice
Models, Animal
Mutant Proteins - genetics
Mutant Proteins - metabolism
Mutation
Neovascularization, Pathologic
Phenotype
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Description
Summary:The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collagen and prolyl hydroxylases lead to altered microenvironment and defective angiogenesis.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2012.08.022