Phosphoglucomutase Activity as a Novel Biomarker in Patients With Acute Myocardial Infarction

Background: Phosphoglucomutase (PGM), a key enzyme in cellular glucose utilization and energy homeostasis, has been reported to show a relationship with oxidative stress. However, the clinical importance of PGM activity has not been investigated in patients with ischemic heart disease (IHD). The aim...

Full description

Saved in:
Bibliographic Details
Published in:Circulation Journal 2012, Vol.76(9), pp.2197-2203
Main Authors: Nishinari, Makoto, Aoyama, Naoyoshi, Ogawa, Zensuke, Yukino, Shogo, Oka, Shusaku, Yano, Kouji, Kurosaki, Yoshifumi, Takeuchi, Ichiro, Imaki, Ryuta, Tojo, Taiki, Shimohama, Takao, Takehana, Hitoshi, Izumi, Tohru
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Adult
Aged
Angina, Stable - blood
Angina, Stable - enzymology
Animals
Biomarkers - blood
Cattle
Female
Humans
Male
Middle Aged
Myocardial Infarction - enzymology
Phosphoglucomutase - blood
Phosphoglucomutase activity
Pilot Projects
ST-elevation myocardial infarction
Thrombosis - blood
Thrombosis - enzymology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Phosphoglucomutase (PGM), a key enzyme in cellular glucose utilization and energy homeostasis, has been reported to show a relationship with oxidative stress. However, the clinical importance of PGM activity has not been investigated in patients with ischemic heart disease (IHD). The aim of the present pilot study was to clarify whether PGM activity has potential as a cardiovascular risk predictor in patients with IHD. Methods and Results: The levels of serum PGM activity in 237 patients with IHD (63 patients with acute myocardial infarction (AMI) and 174 patients with stable effort angina pectoris (EAP)) were evaluated. PGM activity was compared with levels of various myocardial, thrombosis, and inflammatory biomarkers on admission. PGM activity in the AMI group was significantly increased relative to that in the EAP group on admission (AMI, 55.5μmol·min–1·L–1 (U/L); EAP, 14.4U/L (P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-11-1444