Impaired Myocardial Perfusion Reserve in Patients With Fatty Liver Disease Assessed by Quantitative Myocardial Perfusion Magnetic Resonance Imaging

• Published in: Circulation Journal 2012, Vol.76(9), pp.2234-2240
• Main Authors: Nakamori, Shiro, Onishi, Katsuya, Nakajima, Hiroshi, Yoon, Yeonyee Elizabeth, Nagata, Motonori, Kurita, Tairo, Yamada, Tomomi, Kitagawa, Kakuya, Dohi, Kaoru, Nakamura, Mashio, Sakuma, Hajime, Ito, Masaaki
• Format: Article
• Language: English
• Subjects: Abdominal computed tomography; Aged; Blood Flow Velocity; Cardiac magnetic resonance; Fatty liver; Fatty Liver - diagnostic imaging; Fatty Liver - physiopathology; Female; Fractional Flow Reserve, Myocardial; Heart Ventricles - diagnostic imaging; Heart Ventricles - physiopathology; Humans; Magnetic Resonance Angiography; Male; Microcirculation; Middle Aged; Myocardial Ischemia - diagnostic imaging; Myocardial Ischemia - physiopathology; Myocardial perfusion reserve; Non-alcoholic Fatty Liver Disease; Radiography; Retrospective Studies
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-11-1487

Background: The purpose of this study was to determine whether the presence of fatty liver is associated with an alteration in myocardial perfusion reserve (MPR). Methods and Results: A retrospective analysis of 65 asymptomatic subjects who underwent both plain abdominal computed tomography and cardiac magnetic resonance imaging (MRI), and who had normal left ventricular wall motion, no regional myocardial ischemia and no myocardial scar on MRI was performed. Stress and rest myocardial perfusion MRI were analyzed by Patlak plot method to quantify myocardial blood flow (MBF) and MPR in 16 myocardial segments. Fatty liver was detected in 18 (28%) of the 65 subjects. No significant difference was found in rest-MBF between subjects with and without fatty liver (1.2±0.75 vs. 1.1±0.67ml·min–1·g−1, P=0.59). However, MPR was significantly lower in subjects with fatty liver than the non-fatty liver subjects (2.3±0.74 vs. 3.3±1.4, P