Anti-proliferative Activity and Apoptotic Potential of Britannin, a Sesquiterpene Lactone from Inula aucheriana

Inula aucheriana n-hexane, CHCl3 and MeOH extracts were evaluated for their anti-proliferative activity against HepG-2, MCF-7, MDBK and A-549 cells. The CHCl3 extract exhibited cytotoxic activity to the above cell lines with IC50 values of 13.5, 23.4, 10.5, and 26.9 μg/mL, respectively. The sesquite...

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Bibliographic Details
Published in:Natural product communications 2012-08, Vol.7 (8), p.979-980
Main Authors: Moghadam, Maryam Hamzeloo, Hajimehdipoor, Homa, Saeidnia, Soodabeh, Atoofi, Azadeh, Shahrestani, Roxana, Read, Roger W., Mosaddegh, Mahmoud
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Apoptosis - drug effects
Cell Line, Tumor
Humans
Inula - chemistry
Lactones - chemistry
Lactones - pharmacology
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
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Summary:Inula aucheriana n-hexane, CHCl3 and MeOH extracts were evaluated for their anti-proliferative activity against HepG-2, MCF-7, MDBK and A-549 cells. The CHCl3 extract exhibited cytotoxic activity to the above cell lines with IC50 values of 13.5, 23.4, 10.5, and 26.9 μg/mL, respectively. The sesquiterpene lactone britannin was isolated from the above extract. This was further evaluated in the MTT assay to demonstrate strong cytotoxicity to the mentioned cell lines (IC50: 2.2, 5.9, 5.4, and 3.5 μg/mL, respectively), and the apoptotic inducing properties of britannin were evaluated on human breast adenocarcinoma (MCF-7) cells through the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1200700804