A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells

Highlights ► ADAM10 and 17 are overexpressed in human glioma tissue and tumor spheres. ► ADAM10/17 promote the growth of tumor spheres. ► ADAM10/17 promote sphere-forming cells symmetric self-renewal division versus neuronal differentiation.

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Bibliographic Details
Published in:Cancer letters 2012-12, Vol.326 (1), p.79-87
Main Authors: Bulstrode, Harry, Jones, Louise M, Siney, Elodie J, Sampson, Jessica M, Ludwig, Andreas, Gray, William P, Willaime-Morawek, Sandrine
Format: Article
Language:English
Subjects:
ADAM Proteins - antagonists & inhibitors
ADAM Proteins - metabolism
ADAM10
ADAM10 Protein
ADAM17
Amyloid Precursor Protein Secretases - metabolism
Brain cancer
Brain Neoplasms - metabolism
Brain research
Brain tumor
Cell Differentiation
Cell division
Cell growth
Cell Proliferation
Cell Survival
Ethics
Fertilins
Glioma - metabolism
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Ligands
Medical prognosis
Membrane Glycoproteins - metabolism
Membrane Proteins - metabolism
Neoplastic Stem Cells - metabolism
Population
Spheroids, Cellular
Stem cells
Survival analysis
Tumor Cells, Cultured
Tumors
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Description
Summary:Highlights ► ADAM10 and 17 are overexpressed in human glioma tissue and tumor spheres. ► ADAM10/17 promote the growth of tumor spheres. ► ADAM10/17 promote sphere-forming cells symmetric self-renewal division versus neuronal differentiation.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.07.022