Relationship of seminal plasma antioxidants and serum male hormones with sperm chromatin status in male factor infertility

We explored the relationship between sperm chromatin integrity, hormone levels, seminal plasma total antioxidant capacity (TAC), and routine sperm parameters in men with male factor (MF, n = 81) and non-male factor (NMF, n = 52) infertility. Semen and blood were collected and examined from men under...

Full description

Saved in:
Bibliographic Details
Published in:Systems biology in reproductive medicine 2012-10, Vol.58 (5), p.236-244
Main Authors: Lakpour, Niknam, Mahfouz, Reda Z, Akhondi, Mohammad Mehdi, Agarwal, Ashok, Kharrazi, Hadi, Zeraati, Hojjat, Amirjannati, Naser, Sadeghi, Mohammad Reza
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antioxidants - analysis
Biomarkers - blood
Chromatin Assembly and Disassembly
chromomycin A
Dehydroepiandrosterone - blood
DHEA
Estradiol - blood
Follicle Stimulating Hormone, Human - blood
Hormones - blood
Humans
Infertility, Male - blood
Infertility, Male - diagnosis
Infertility, Male - genetics
Infertility, Male - pathology
Iran
Linear Models
Luteinizing Hormone - blood
Male
male infertility
Middle Aged
Multivariate Analysis
Semen - chemistry
Semen Analysis
seminal plasma TAC
sperm DNA damage
Spermatozoa - metabolism
Spermatozoa - pathology
Testosterone - blood
toluidine blue
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We explored the relationship between sperm chromatin integrity, hormone levels, seminal plasma total antioxidant capacity (TAC), and routine sperm parameters in men with male factor (MF, n = 81) and non-male factor (NMF, n = 52) infertility. Semen and blood were collected and examined from men undergoing evaluation for infertility in the Avicenna Infertility Clinic. We have examined each patient for serum hormones (LH, FSH, E2, DHEA), sperm chromatin damage, level of protamination and seminal plasma TAC. Levels of FSH, LH, sperm chromatin damage, and abnormal protamination were significantly higher in MF vs. NMF groups (p 
ISSN:1939-6368
1939-6376
DOI:10.3109/19396368.2012.689923