A hazardous link between malnutrition, inflammation and oxidative stress in renal patients

Atherosclerosis is the main cause of mortality in end stage renal disease (ESRD) patients. Malnutrition, inflammation and diminished paraoxonase activity were used to calculate the sum of risk factors for atherosclerosis development in a cohort of 141 chronic renal disease patients. Kaplan–Meier sur...

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Bibliographic Details
Published in:Clinical biochemistry 2012-10, Vol.45 (15), p.1202-1205
Main Authors: Kotur-Stevuljevic, Jelena, Simic-Ogrizovic, Sanja, Dopsaj, Violeta, Stefanovic, Aleksandra, Vujovic, Ana, Ivanic-Corlomanovic, Tatjana, Spasic, Slavica, Kalimanovska-Spasojevic, Vesna, Jelic-Ivanovic, Zorana
Format: Article
Language:English
Subjects:
Adult
Aryldialkylphosphatase - blood
Biological and medical sciences
Case-Control Studies
Dyslipidemias - blood
Dyslipidemias - etiology
Female
Humans
Inflammation
Inflammation - blood
Inflammation - etiology
Investigative techniques, diagnostic techniques (general aspects)
Kaplan-Meier Estimate
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - therapy
Male
Malnutrition
Malnutrition - blood
Malnutrition - etiology
Medical sciences
Metabolic diseases
Middle Aged
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Oxidative Stress
Paraoxonase-1
Prospective Studies
Renal Dialysis
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Summary:Atherosclerosis is the main cause of mortality in end stage renal disease (ESRD) patients. Malnutrition, inflammation and diminished paraoxonase activity were used to calculate the sum of risk factors for atherosclerosis development in a cohort of 141 chronic renal disease patients. Kaplan–Meier survival analysis was implemented to assess risk of death. Kaplan–Meier analysis (Log rank=12.06, P=0.0072) showed higher risk of death with increasing number of risk factors in haemodialysis patients. Malnutrition in combination with inflammation and oxidative stress is associated with higher mortality in patients on long-term haemodialysis. ► Cardiovascular diseases are the major cause of mortality of renal disease patients. ► Oxidative stress is novel emerging risk factor for atherosclerosis development. ► Paraoxonase activity is diminished in renal disease patients.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2012.04.021