Predictive factors of response to intravenous ciclosporin in severe ulcerative colitis: the development of a novel prediction formula

Summary Background When treating patients with severe ulcerative colitis (UC), accurate prediction of drug efficacy contributes to early clinical decision‐making. Aim To identify predictive factors and to develop a reliable prediction formula and a decision tree of response to intravenous ciclospori...

Full description

Saved in:
Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2012-10, Vol.36 (8), p.744-754
Main Authors: Saito, K., Katsuno, T., Nakagawa, T., Saito, M., Sazuka, S., Sato, T., Matsumura, T., Arai, M., Miyauchi, H., Matsubara, H., Yokosuka, O.
Format: Article
Language:English
Subjects:
Administration, Intravenous
Adolescent
Adult
Aged
Biological and medical sciences
Colitis, Ulcerative - drug therapy
Cyclosporine - administration & dosage
Digestive system
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunosuppressive Agents - administration & dosage
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Pharmacology. Drug treatments
Predictive Value of Tests
Severity of Illness Index
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Treatment Outcome
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background When treating patients with severe ulcerative colitis (UC), accurate prediction of drug efficacy contributes to early clinical decision‐making. Aim To identify predictive factors and to develop a reliable prediction formula and a decision tree of response to intravenous ciclosporin treatment for severe UC. Methods Patients included in this study were those diagnosed with refractory severe UC who had undergone ciclosporin treatment between December 2004 and March 2011 at a tertiary referral centre in Japan. Demographic and clinical parameters from all patients were analysed by multivariate statistics. Results Fifty‐two patients were included in this study (36.5% men with an average age of ciclosporin initiation of 40.2 ± 15.6 years). Thirty‐four patients (65.4%) were responders to the treatment with ciclosporin and avoided colectomy, 18 patients (34.6%) were nonresponders and underwent colectomy. Stepwise multiple logistic regression analysis identified four independent predictive factors of response to intravenous ciclosporin: age at hospitalisation (AGE), platelet count (×104/μL) on the first day (PLA), Lichtiger score on the third day (LIC) and total protein (g/dL) on the third day minus total protein on the first day (ΔTP). The calculation formula (8.5 − 0.16 × AGE + 0.21 × PLA − 0.61 × LIC + 2.3 × ΔTP 
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.12033