Expression of midkine in ameloblastomas and its correlation with clinicopathologic parameters

Objective Midkine (MK) is a heparin-binding growth factor that is overexpressed in various human cancers. The aim of this study was to investigate the expression of MK in ameloblastomas and correlate the results with clinicopathologic parameters. Study Design Cases of ameloblastoma seen between 1999...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2012-10, Vol.114 (4), p.497-502
Main Authors: Scheper, Mark A., DDS, PhD, Duarte, Eliza C.B., DDS, MS, PhD, Intapa, Chaidan, DDS, Zhang, Ming, MD, Nascimento, Lenin M, Almeida, Thauanne P, Gomes, Ana C, Song, Sharon, Chaisuparat, Risa, Batista, Aline C., DDS, MS, PhD, Jham, Bruno C., DDS, MS, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Ameloblastoma - metabolism
Ameloblastoma - pathology
Biological and medical sciences
Child
Cytokines - metabolism
Dentistry
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Humans
Immunohistochemistry
Jaw Neoplasms - metabolism
Jaw Neoplasms - pathology
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Surgery
Tumors
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Summary:Objective Midkine (MK) is a heparin-binding growth factor that is overexpressed in various human cancers. The aim of this study was to investigate the expression of MK in ameloblastomas and correlate the results with clinicopathologic parameters. Study Design Cases of ameloblastoma seen between 1999 and 2010 were identified. Clinical information was collected regarding age, gender, race, and location of tumor. Cases were classified as solid/multicystic, unicystic, and peripheral. The expression of midkine was assessed using immunohistochemistry. A significant difference was considered present at P < 0.05. Results A total of 34 cases of ameloblastoma and 4 cases of ameloblastic carcinomas were identified. MK was expressed in 67% of lesions (23.5% weak expression; 14.7% moderate expression; 29.4% strong expression). A significant difference was seen between solid/multicystic and unicystic lesions. Conclusions MK is expressed in the majority of ameloblastomas, suggesting a role of the protein in the tumor's development, progression, and behavior.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2012.06.013