Tunable Fusion and Aggregation of Liposomes Triggered by Multifunctional Surface-Cross-Linked Micelles

Water-soluble organic nanoparticles were prepared by cross-linking the micelles of a tripropargylated cationic surfactant by a diazide cross-linker in the presence of Cu(I) catalysts. The nanoparticles were decorated with hydrophilic ligands of different lengths on the surface. By interacting with n...

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Bibliographic Details
Published in:Bioconjugate chemistry 2012-09, Vol.23 (9), p.1721-1725
Main Authors: Li, Xueshu, Zhao, Yan
Format: Article
Language:English
Subjects:
Catalysts
Copper
Liposomes
Membranes
Micelles
Molecules
Nanoparticles
Surfactants
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Summary:Water-soluble organic nanoparticles were prepared by cross-linking the micelles of a tripropargylated cationic surfactant by a diazide cross-linker in the presence of Cu(I) catalysts. The nanoparticles were decorated with hydrophilic ligands of different lengths on the surface. By interacting with negatively charged liposomes through tunable electrostatic interactions, these nanoparticles induced fusion and leakage of large unilamellar vesicles (LUVs). Fusion or aggregation of the membranes was highly sensitive to the rigidity and phase structures of the membranes, enabling thermally gated fusion to occur within a very narrow window of temperature change.
ISSN:1043-1802
1520-4812
DOI:10.1021/bc300082b