Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk

• Published in: Archives of toxicology 2012-09, Vol.86 (9), p.1369-1378
• Main Authors: Selinski, Silvia, Lehmann, Marie-Louise, Blaszkewicz, Meinolf, Ovsiannikov, Daniel, Moormann, Oliver, Guballa, Christoph, Kress, Alexander, Truß, Michael C., Gerullis, Holger, Otto, Thomas, Barski, Dimitri, Niegisch, Günter, Albers, Peter, Frees, Sebastian, Brenner, Walburgis, Thüroff, Joachim W., Angeli-Greaves, Miriam, Seidel, Thilo, Roth, Gerhard, Volkert, Frank, Ebbinghaus, Rainer, Prager, Hans M., Bolt, Hermann M., Falkenstein, Michael, Zimmermann, Anna, Klein, Torsten, Reckwitz, Thomas, Roemer, Hermann C., Hartel, Mark, Weistenhöfer, Wobbeke, Schöps, Wolfgang, Rizvi, S. Adibul Hassan, Aslam, Muhammad, Bánfi, Gergely, Romics, Imre, Ickstadt, Katja, Hengstler, Jan G., Golka, Klaus
• Format: Article
• Language: English
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Bladder; Bladder cancer; Cancer; Carcinogens, Environmental - administration & dosage; Carcinogens, Environmental - pharmacokinetics; Carcinogens, Environmental - toxicity; Chromosomes; Chromosomes, Human, Pair 2 - genetics; Environmental Health; Enzymes; Genetic Association Studies; Genetic Loci; Genetic Predisposition to Disease; Glucuronosyltransferase - genetics; Glucuronosyltransferase - metabolism; Humans; Inactivation, Metabolic; Introns; Isoenzymes - genetics; Isoenzymes - metabolism; Multigene Family; Occupational Exposure; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; Polycyclic aromatic hydrocarbons; Polymorphism; Polymorphism, Single Nucleotide; Risk; Smoking - adverse effects; Toxicogenetics - methods; Toxicogenomics; Toxicology; Urinary Bladder Neoplasms - chemically induced; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism
• ISSN: 0340-5761; 1432-0738
• DOI: 10.1007/s00204-012-0854-y

Recently, rs11892031[A] has been identified in a genome-wide association study (GWAS) to confer increased risk of urinary bladder cancer (UBC). To confirm this association and additionally study a possible relevance of exposure to urinary bladder carcinogens, we investigated the IfADo UBC study group, consisting of eight case–control series from different regions including 1,805 cases and 2,141 controls. This analysis was supplemented by a meta-analysis of all published data, including 13,395 cases and 54,876 controls. Rs11892031 A/A was significantly associated with UBC risk in the IfADo case–control series adjusted to cigarette smoking, gender, age and ethnicity (OR = 1.18; 95% CI = 1.02–1.37; P  = 0.026). In the meta-analysis, a convincing association with UBC risk was obtained (OR = 1.19; 95% Cl = 1.12–1.26; P