Spontaneous Cerebellar Primitive Neuroectodermal Tumor in a Juvenile Cynomolgus Monkey (Macaca fascicularis)

A neoplastic mass compressing the left cerebellar hemisphere and hindbrain was observed at trimming in a 3½-year-old male cynomolgus monkey from a control dose group. Microscopically, the neoplastic mass was nonencapsulated, invasive, and showed two morphological patterns. The predominant area consi...

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Bibliographic Details
Published in:Toxicologic pathology 2012-08, Vol.40 (6), p.931-934
Main Authors: Mukaratirwa, Sydney, Rogerson, Petrina, Blanco, Ana L., Naylor, Stuart W., Bradley, Alys
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cerebellar Neoplasms - diagnosis
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - physiopathology
Cerebellar Neoplasms - veterinary
Cerebellum - chemistry
Cerebellum - pathology
Cynomolgus
Histocytochemistry
Macaca fascicularis
Male
Medical sciences
Medulloblastoma - diagnosis
Medulloblastoma - pathology
Medulloblastoma - physiopathology
Medulloblastoma - veterinary
Monkey Diseases - diagnosis
Monkey Diseases - pathology
Monkey Diseases - physiopathology
Neuroectodermal Tumors, Primitive - diagnosis
Neuroectodermal Tumors, Primitive - pathology
Neuroectodermal Tumors, Primitive - physiopathology
Neuroectodermal Tumors, Primitive - veterinary
Primates
Toxicology
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Summary:A neoplastic mass compressing the left cerebellar hemisphere and hindbrain was observed at trimming in a 3½-year-old male cynomolgus monkey from a control dose group. Microscopically, the neoplastic mass was nonencapsulated, invasive, and showed two morphological patterns. The predominant area consisted of densely packed undifferentiated, polygonal to spindle cells arranged in vague sheets supported by a scant fibrovascular stroma. The other area was less cellular and composed of round neoplastic cells separated by eosinophilic fibrillar material. Immunohistochemical staining for vimentin, synaptophysin, glial fibrillary acidic protein, neuron-specific enolase, neurofilament, and S-100 confirmed the presence of primitive undifferentiated neuroectodermal cells and some cells with neuronal or glial differentiation. On the basis of histopathology and immunohistochemical findings, a diagnosis of cerebellar primitive neuroectodermal tumor with neuronal and glial differentiation was made. Primitive neuroectodermal tumors are rare in animals including nonhuman primates; this is the first published report in this species.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623312444764