Expression of toll-like receptor 2 and plasma level of interleukin-10 are associated with outcome in tuberculosis

Toll-like receptor (TLR) 2-mediated innate immunity is an important defense system against Mycobacterium tuberculosis infection. Studies on TLR2 protein expression and downstream cytokines in tuberculosis patients are lacking. TLR2 expression in the peripheral blood monocytes of 87 tuberculosis pati...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2012-09, Vol.31 (9), p.2327-2333
Main Authors: Wang, J.-Y., Chang, H.-C., Liu, J.-L., Shu, C.-C., Lee, C.-H., Wang, J.-T., Lee, L.-N.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Antibodies
Antigens
Bacterial diseases
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cytokines
Dendritic cells
Female
Flow cytometry
gamma -Interferon
Hospitals
Human bacterial diseases
Humans
Immune system
Immunity
Infection
Infectious diseases
Inflammation
Interleukin 10
Interleukin-10 - blood
Internal Medicine
Leukocytes, Mononuclear - immunology
Male
Medical Microbiology
Medical sciences
Middle Aged
Monocytes
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Peripheral blood
Plasma
Plasma - immunology
Plasma levels
Prognosis
Prospective Studies
Regression analysis
Sputum
Survival
TLR2 protein
Toll-Like Receptor 2 - analysis
Toll-like receptors
Treatment Outcome
Tuberculosis
Tuberculosis - diagnosis
Tuberculosis - immunology
Tuberculosis and atypical mycobacterial infections
Tumor necrosis factor
Tumor necrosis factor-TNF
Young Adult
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Summary:Toll-like receptor (TLR) 2-mediated innate immunity is an important defense system against Mycobacterium tuberculosis infection. Studies on TLR2 protein expression and downstream cytokines in tuberculosis patients are lacking. TLR2 expression in the peripheral blood monocytes of 87 tuberculosis patients and 94 healthy subjects was evaluated using flow cytometry. TLR2 expression and its downstream cytokines, including interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-alpha, and interferon-gamma, were correlated with the clinical manifestations and outcomes of tuberculosis. The TLR2 expression in peripheral blood monocytes was higher in tuberculosis patients than in healthy subjects. Among the tuberculosis patients, those aged ≥70 years with disseminated tuberculosis or aged
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-012-1572-3