Clinical significance of enzymatic lysophosphatidylcholine (LPC) assay data in patients with sepsis

Lysophosphatidylcholine (LPC) has been suggested to serve as a useful prognostic marker for sepsis. However, existing LPC assays are complicated, time-consuming, and of limited application in real clinical situations. Thus, we investigated the serum LPC levels in sepsis patients using an enzymatic a...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2012-08, Vol.31 (8), p.1805-1810
Main Authors: Cho, W. H., Park, T., Park, Y. Y., Huh, J. W., Lim, C.-M., Koh, Y., Song, D.-K., Hong, S.-B.
Format: Article
Language:English
Subjects:
Aged
Bacteremia
Bacteria
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Blood
Blood & organ donations
Blood donors
Clinical Laboratory Techniques - methods
Clinical significance
Critical care
Data processing
Female
Gram-negative bacteria
Gram-positive bacteria
Human bacterial diseases
Humans
Infections
Infectious diseases
Internal Medicine
Lysophosphatidylcholine
Lysophosphatidylcholines - blood
Male
Medical Microbiology
Medical sciences
Medicine
Middle Aged
Mortality
Organisms
Pathogens
Patients
Prospective Studies
Sepsis
Sepsis - diagnosis
Sepsis - mortality
Sepsis - pathology
Serum - chemistry
Severity of Illness Index
Statistical analysis
Variance analysis
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Summary:Lysophosphatidylcholine (LPC) has been suggested to serve as a useful prognostic marker for sepsis. However, existing LPC assays are complicated, time-consuming, and of limited application in real clinical situations. Thus, we investigated the serum LPC levels in sepsis patients using an enzymatic assay and analyzed the correlations between the serum LPC concentration and clinical characteristics. We prospectively collected blood samples from suspected sepsis patients, commencing on day 1 of sepsis. We analyzed all samples using an enzymatic assay. Additionally, we analyzed the serum LPC concentrations in a control group of 21 healthy blood donors. A total of 105 patients who fulfilled the sepsis criteria were included. The mean serum LPC concentration was 43.49 ± 33.09 μmol/L in sepsis patients, which was much lower than that of 21 healthy controls (234.68 ± 30.33 μmol/L, p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-011-1505-6