Testicular Development in Cynomolgus Monkeys

The testes from 136 male cynomolgus monkeys were examined histopathologically in order to investigate the relationship between the development of spermatogenesis and testis weight, age, and body weight. At Grade 1 (immature), Sertoli cells and spermatogonia were the only cell classes in the testis....

Full description

Saved in:
Bibliographic Details
Published in:Toxicologic pathology 2012-08, Vol.40 (6), p.935-942
Main Authors: Haruyama, Emiko, Suda, Masakazu, Ayukawa, Yuki, Kamura, Koshiro, Mizutamari, Megumi, Ooshima, Yojiro, Tanimoto, Akihide
Format: Article
Language:English
Subjects:
Age
Age Factors
Animals
Biological and medical sciences
Body Weight
Cynomolgus
Development
Epididymis
Epididymis - growth & development
Germ cells
Histocytochemistry
Logistic Models
Macaca fascicularis - growth & development
Male
Maturity
Medical sciences
Organ Size - physiology
Puberty
Regression analysis
Seminiferous tubule
Sertoli cells
Sexual Maturation - physiology
Sperm
Spermatids
Spermatogenesis
Spermatogenesis - physiology
Spermatogonia
Testes
Testis - growth & development
Testis - physiology
Toxicology
Tubules
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The testes from 136 male cynomolgus monkeys were examined histopathologically in order to investigate the relationship between the development of spermatogenesis and testis weight, age, and body weight. At Grade 1 (immature), Sertoli cells and spermatogonia were the only cell classes in the testis. At Grade 2 (pre-puberty), no elongated spermatids were observed in the testis, although a few round spermatids and small lumen formation were observed. At Grade 3 (onset of puberty), all classes of germ cells were observed in the testis, although seminiferous tubule diameters and numbers of germ cells were small. Slight debris in the epididymis was observed in almost all animals. At Grade 4 (puberty), almost complete spermatogenesis was observed in the seminiferous tubules and it was possible to ascertain the spermatogenesis stage as described by Clermont, although tubule diameters and numbers of germ cells were small. There was less debris in the epididymis than at Grade 3. At Grade 5 (early adult), complete spermatogenesis was observed in the seminiferous tubules. At Grade 6 (adult), complete spermatogenesis in the seminiferous tubules and a moderate or large number of sperm in the epididymis were observed. Moreover, sperm analysis using ejaculated sperm was possible. Logistic regression analysis showed that testis weight is a good indicator of testicular maturity.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623312444619