Low molecular weight Delta b-glucan stimulates doxorubicin-induced suppression of immune functions in mice

The aim of this study was to evaluate the protective effect of low molecular weight Delta *b-glucan (LMG) against doxorubicin (DOX)-induced immune suppression of tumor-bearing mice. The tumor size and spleen cell functions such as spleen cell proliferation, cytokine production (interferon- Delta *g...

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Bibliographic Details
Published in:Food science and biotechnology 2012-06, Vol.21 (3), p.645-651
Main Authors: Sung, Nak-Yun, Byun, Eui-Baek, Song, Du-Sup, Yoo, Young-Choon, Kim, Jae-Kyung, Park, Jong-Heum, Song, Beom-Seok, Park, Sang-Hyun, Lee, Ju-Woon, Yu, Young-Beob
Format: Article
Language:English
Subjects:
CD4 antigen
CD8 antigen
Cell proliferation
Cell size
Doxorubicin
Immune response
Interleukin 2
Lymphocytes T
Spleen
Splenocytes
Toxicity
Tumors
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Summary:The aim of this study was to evaluate the protective effect of low molecular weight Delta *b-glucan (LMG) against doxorubicin (DOX)-induced immune suppression of tumor-bearing mice. The tumor size and spleen cell functions such as spleen cell proliferation, cytokine production (interferon- Delta *g and interleukin-2), and the population of CD4+ and CD8+ T cells were estimated. In the tumorbearing mice, the tumor size was significantly (p
ISSN:1226-7708
DOI:10.1007/s10068-012-0084-3