Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria

Quorum sensing is a form of intercellular communication used by many species of bacteria that facilitates concerted interactions between the cells comprising a population. The phenotypes regulated by quorum sensing are extremely diverse, with many having a significant impact upon healthcare, agricul...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2012-09, Vol.20 (9), p.449-458
Main Authors: Galloway, Warren R.J.D, Hodgkinson, James T, Bowden, Steven, Welch, Martin, Spring, David R
Format: Article
Language:English
Subjects:
Agriculture
antibacterial
bacteria
case studies
cell communication
communication
Environment
Gram-negative bacteria
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - physiology
Health
health services
Humans
Internal Medicine
phenotype
quorum sensing
Quorum Sensing - drug effects
Quorum Sensing - physiology
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Summary:Quorum sensing is a form of intercellular communication used by many species of bacteria that facilitates concerted interactions between the cells comprising a population. The phenotypes regulated by quorum sensing are extremely diverse, with many having a significant impact upon healthcare, agriculture, and the environment. Consequently there has been significant interest in developing methods to manipulate this signalling process and recent years have witnessed significant theoretical and practical developments. A wide range of small molecule modulators of quorum sensing systems has been discovered, providing an expansive chemical toolbox for the study and modulation of this signalling mechanism. In this review, a selection of recent case studies which illustrate the value of both activators and inhibitors of quorum sensing in Gram-negative bacteria are discussed.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2012.06.003