The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome

The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor and evolutionary member of the immunoglobulin superfamily that is involved in the host response to infection, injury, and inflammation. It exists in two forms: membrane-bound and soluble forms (sRAGE). RAGE rec...

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Bibliographic Details
Published in:Intensive care medicine 2012-10, Vol.38 (10), p.1588-1598
Main Authors: Guo, Weidun Alan, Knight, Paul R., Raghavendran, Krishnan
Format: Article
Language:English
Subjects:
Acute Lung Injury - metabolism
Acute respiratory distress syndrome
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesiology
Biological and medical sciences
Biomarkers
Critical Care Medicine
Cytokines
Emergency and intensive respiratory care
Emergency Medicine
Glycation End Products, Advanced - metabolism
Health aspects
Humans
Immune system
Immunoglobulins
Inflammation
Inflammation - metabolism
Inflammation - pathology
Intensive
Intensive care
Intensive care medicine
Kinases
Ligands
Lung - metabolism
Lung - pathology
Medical sciences
Medicine
Medicine & Public Health
Mitochondrial DNA
Pain Medicine
Pathogenesis
Pattern recognition
Pediatrics
Peptides
Pneumology/Respiratory System
Proteins
Receptor for Advanced Glycation End Products
Receptors, Immunologic - metabolism
Respiratory distress syndrome
Respiratory Distress Syndrome, Adult - metabolism
Respiratory Distress Syndrome, Adult - pathology
Respiratory failure
Review
Signal Transduction
Transcription factors
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Description
Summary:The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor and evolutionary member of the immunoglobulin superfamily that is involved in the host response to infection, injury, and inflammation. It exists in two forms: membrane-bound and soluble forms (sRAGE). RAGE recognizes a variety of ligands and, via a receptor-driven signaling cascade, activates the transcription factor NF-κB, leading to the expression of proinflammatory cytokines. The soluble form, sRAGE, is a decoy receptor and competitively inhibits membrane RAGE activation. RAGE is constitutively expressed abundantly in the lung under basal conditions. This expression is enhanced during inflammatory states such as with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). This review summarizes the characteristics of RAGE, RAGE isoforms, RAGE ligands, and signaling pathways in the pathogenesis of ALI and ARDS. Additionally, the review explores the potential of RAGE as an important therapeutic target in ALI/ARDS.
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-012-2624-y