The Role of Cetuximab in the Treatment of Metastatic Colorectal Cancer

Targeted biological therapy is becoming a standard in personalized medicine for patients with advanced stages of cancer. Treatment with cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, represents an example of personalized anticancer therapy for patients with metastatic colorecta...

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Bibliographic Details
Published in:Anticancer research 2012-09, Vol.32 (9), p.4007-4011
Main Authors: HOLUBEC, Lubos, LISKA, Vaclav, MATEJKA, Vit M, FIALA, Ondrej, DRESLEROVA, Jana, MRAZKOVA, Petra, TRESKA, Vladislav, FINEK, Jindrich
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Humanized
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Cetuximab
Colorectal Neoplasms - drug therapy
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Tumors
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Summary:Targeted biological therapy is becoming a standard in personalized medicine for patients with advanced stages of cancer. Treatment with cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, represents an example of personalized anticancer therapy for patients with metastatic colorectal cancer and wild (non-mutated) type of the Kirsten rat sarcoma viral oncogene (KRAS). Here the role of cetuximab in treating metastatic colorectal cancer is discussed with a focus on the treatment of hepatic metastases.
ISSN:0250-7005
1791-7530