Resistin-like molecule-β is induced following bronchoconstriction of asthmatic airways

ABSTRACT Background and objective:  Resistin‐like molecule‐β (RELM‐β) is a necessary and sufficient stimulus for airway remodelling in animal models of asthma, but until recently, its role in human disease had not been investigated. The hypothesis that RELM‐β expression would increase with increasin...

Full description

Saved in:
Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2012-10, Vol.17 (7), p.1094-1100
Main Authors: GRAINGE, CHRISTOPHER, DULAY, VALDEEP, WARD, JONATHAN, SAMMUT, DAVID, DAVIES, ELIZABETH, GREEN, BENJAMIN, LAU, LAURIE, COTTEY, LAURA, HAITCHI, HANS-MICHAEL, DAVIES, DONNA E., HOWARTH, PETER H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Airway Remodeling - immunology
allergen
Allergens - immunology
asthma
Asthma - immunology
Asthma - metabolism
Bronchial Provocation Tests
Bronchoconstriction - immunology
Bronchoscopy
Humans
Immunohistochemistry
Intercellular Signaling Peptides and Proteins - metabolism
methacholine
Methacholine Chloride
Middle Aged
remodelling
resistin-like molecule-β
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Background and objective:  Resistin‐like molecule‐β (RELM‐β) is a necessary and sufficient stimulus for airway remodelling in animal models of asthma, but until recently, its role in human disease had not been investigated. The hypothesis that RELM‐β expression would increase with increasing asthma severity and further increase following acute bronchoconstrictor challenges has been examined. Methods:  Bronchial biopsies from healthy subjects and patients with mild and severe asthma were immunostained for RELM‐β, as were airway biopsies obtained in mild asthmatics before and 4 days after repeated inhalation challenges with either allergen, methacholine or methacholine preceded by salbutamol as a control. Bronchial brushings were also evaluated for RELM‐β mRNA. Results:  RELM‐β immunoreactivity, which co‐localized to airway epithelial cells, increased with disease severity; healthy volunteers, median per cent epithelial area 1.98%, mild asthma 3.49% and severe asthma 5.89% (P 
ISSN:1323-7799
1440-1843
DOI:10.1111/j.1440-1843.2012.02215.x