KI-catalyzed imidation of sp3 C-H bond adjacent to amide nitrogen atom

We have developed a new KI-catalyzed method for the imidation of an sp(3) C-H bond adjacent to an amide nitrogen atom by using TBHP (tert-butyl hydroperoxide, 70% aqueous solution) as the oxidant. This novel procedure tolerated air and moisture and provided a series of novel products in moderate to...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2012-10, Vol.10 (39), p.7869-7871
Main Authors: Lao, Zhi-Qi, Zhong, Wen-He, Lou, Qing-Hua, Li, Zhong-Jun, Meng, Xiang-Bao
Format: Article
Language:English
Subjects:
Amides - chemistry
Catalysis
Imides - chemical synthesis
Imides - chemistry
Molecular Structure
Potassium Iodide - chemistry
Stereoisomerism
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Summary:We have developed a new KI-catalyzed method for the imidation of an sp(3) C-H bond adjacent to an amide nitrogen atom by using TBHP (tert-butyl hydroperoxide, 70% aqueous solution) as the oxidant. This novel procedure tolerated air and moisture and provided a series of novel products in moderate to excellent yields under mild conditions.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob26430g