Apathy and deep brain stimulation in Parkinson's disease

Apathy was defined by Marin as diminished motivation not attributable to diminished level of consciousness, cognitive impairment, or emotional distress. Up to 42% of Parkinson's disease patients could be concerned. It has a pejorative impact on quality of life and could be predictive of cogniti...

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Bibliographic Details
Published in:Revue neurologique 2012-08, Vol.168 (8-9), p.620-623
Main Authors: Lozachmeur, C, Drapier, D
Format: Article
Language:fre
Subjects:
Apathy - physiology
Cognition Disorders - etiology
Deep Brain Stimulation - adverse effects
Dementia - diagnosis
Dementia - etiology
Humans
Parkinson Disease - complications
Parkinson Disease - diagnosis
Parkinson Disease - psychology
Parkinson Disease - therapy
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Summary:Apathy was defined by Marin as diminished motivation not attributable to diminished level of consciousness, cognitive impairment, or emotional distress. Up to 42% of Parkinson's disease patients could be concerned. It has a pejorative impact on quality of life and could be predictive of cognitive decline. It has been shown that deep brain stimulation in Parkinson's disease may induce apathy. It seems directly related to the stimulation target, i.e. the subthalamic nucleus, since such an effect has not been observed so far in thalamic and pallidal stimulation. It should certainly not make us question the remarkable effectiveness of subthalamic stimulation in Parkinson's disease patients, but encourages us to be very careful about operability criteria. We must, in this sense, improve identification of at risk patients, seeking a thoroughly diminished motivation, loss of interest or blunting affects.
ISSN:0035-3787
DOI:10.1016/j.neurol.2012.06.011