Synthesis of Fluorenone Derivatives through Pd-Catalyzed Dehydrogenative Cyclization

Palladium-catalyzed dual C–H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.

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Bibliographic Details
Published in:Organic letters 2012-09, Vol.14 (18), p.4850-4853
Main Authors: Li, Hu, Zhu, Ru-Yi, Shi, Wen-Juan, He, Ke-Han, Shi, Zhang-Jie
Format: Article
Language:English
Subjects:
Catalysis
Cyclization
Fluorenes - chemical synthesis
Fluorenes - chemistry
Molecular Structure
Oxidation-Reduction
Palladium - chemistry
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Description
Summary:Palladium-catalyzed dual C–H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol302181z