Structure elucidation and NMR assignments of an unusual aromatic monacolin analog from Monascus purpureus-fermented rice

One unusual aromatic monacolin analog, aromonacolin A (1), was isolated from the ethanolic extract of Monascus purpureus‐fermented rice. Its structure was elucidated by extensive spectroscopic (HRESIMS, 1H NMR, 13C NMR, HSQC, HMBC, and NOESY) and chemical methods. The absolute configuration of the C...

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Published in:Magnetic resonance in chemistry 2012-10, Vol.50 (10), p.709-712
Main Authors: Liu, Ming-Tao, Luan, Na, Li, Jin-Jie, Huang, Xiao, Wang, Ye-Feng, Wang, A-Li, Shang, Xiao-Ya
Format: Article
Language:English
Subjects:
absolute configuration
Circular Dichroism
Fermentation
Heptanoates - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
monacolin analog
Monascus - chemistry
Monascus purpureus-fermented rice
Naphthols - chemistry
NMR
Oryza - chemistry
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Summary:One unusual aromatic monacolin analog, aromonacolin A (1), was isolated from the ethanolic extract of Monascus purpureus‐fermented rice. Its structure was elucidated by extensive spectroscopic (HRESIMS, 1H NMR, 13C NMR, HSQC, HMBC, and NOESY) and chemical methods. The absolute configuration of the C‐6 secondary alcohol was deduced via the circular dichroism data of the in situ formed [Rh2(OCOCF3)4] complex. One unusual aromatic monacolin analogue, aromonacolin A (1), was isolated from the ethanolic extract of Monascus purpureus‐fermented rice. Its structure was elucidated by extensive spectroscopic (HRESIMS, 1H NMR, 13C NMR, HSQC, HMBC, and NOESY) and chemical methods. The absolute configuration of the C‐4 secondary alcohol was deduced via the circular dichroism data of the in situ formed [Rh2(OCOCF3)4] complex.
ISSN:0749-1581
1097-458X
DOI:10.1002/mrc.3851