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Eczema Herpeticum in Children: Clinical Features and Factors Predictive of Hospitalization
Objective To describe the clinical characteristics of pediatric patients with eczema herpeticum and to determine the predictors of hospitalization, and recurrence and repeat episodes. Study design A retrospective cohort study of patients 0-18 years of age diagnosed with eczema herpeticum between May...
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| Published in: | The Journal of pediatrics 2012-10, Vol.161 (4), p.671-675 |
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| container_title | The Journal of pediatrics |
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| creator | Luca, Nadia Jennifer Chiara, MD Lara-Corrales, Irene, MD, MSc Pope, Elena, MD, MSc |
| description | Objective To describe the clinical characteristics of pediatric patients with eczema herpeticum and to determine the predictors of hospitalization, and recurrence and repeat episodes. Study design A retrospective cohort study of patients 0-18 years of age diagnosed with eczema herpeticum between May 2000 and April 2009 was carried out at a tertiary pediatric care center in Canada. Seventy-nine patients were included. The primary outcome was hospitalization; secondary outcomes were recurrent and repeat episodes of eczema herpeticum. Results At presentation, 76% of 79 patients with eczema herpeticum had a generalized eruption, 56% had fever, 37% had systemic symptoms, and 10% had eye involvement (keratoconjunctivitis). Forty-five patients (57%) were hospitalized. Predictors for hospitalization included male sex (OR = 3.09; 95% CI, 1.20-7.95, P = .017), fever (OR = 5.75; 95% CI, 2.17-15.26, P < .001), systemic symptoms (OR = 2.84; 95% CI, 1.06-7.62, P = .035), and age |
| doi_str_mv | 10.1016/j.jpeds.2012.03.057 |
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Study design A retrospective cohort study of patients 0-18 years of age diagnosed with eczema herpeticum between May 2000 and April 2009 was carried out at a tertiary pediatric care center in Canada. Seventy-nine patients were included. The primary outcome was hospitalization; secondary outcomes were recurrent and repeat episodes of eczema herpeticum. Results At presentation, 76% of 79 patients with eczema herpeticum had a generalized eruption, 56% had fever, 37% had systemic symptoms, and 10% had eye involvement (keratoconjunctivitis). Forty-five patients (57%) were hospitalized. Predictors for hospitalization included male sex (OR = 3.09; 95% CI, 1.20-7.95, P = .017), fever (OR = 5.75; 95% CI, 2.17-15.26, P < .001), systemic symptoms (OR = 2.84; 95% CI, 1.06-7.62, P = .035), and age <1 year (OR = 7.17; 95% CI, 2.17-23.72, P = .001). Recurrence rate (<1 month) was 8.9% and rate of repeat episodes (>1 month) was 16%. Hospitalized patients were more likely to have a repeat episode (OR = 8.25; 95% CI, 0.99-68.69, P = .05). Patients with a previous history of eczema herpeticum had increased likelihood of early recurrence (OR = 6.80; 95% CI, 0.99-46.62, P = .05) and repeat episodes (OR = 9.43; 95% CI, 1.52-55.9, P = .01). Conclusions Predictors of hospitalization in this cohort included male sex, age <1 year, fever, and systemic symptoms at presentation. Hospitalized patients may be at risk for repeat episodes of eczema herpeticum.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2012.03.057</identifier><identifier>PMID: 22575249</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>Maryland Heights, MO: Elsevier Inc</publisher><subject>Acyclovir - therapeutic use ; Adolescent ; Algorithms ; Antiviral Agents - therapeutic use ; Biological and medical sciences ; Bullous diseases of the skin ; Child ; Child, Preschool ; children ; cohort studies ; Dermatology ; eczema ; eyes ; Female ; fever ; General aspects ; Hospitalization - statistics & numerical data ; Human viral diseases ; Humans ; Infant ; Infectious diseases ; Kaposi Varicelliform Eruption - diagnosis ; Kaposi Varicelliform Eruption - drug therapy ; Kaposi Varicelliform Eruption - therapy ; keratoconjunctivitis ; Male ; Medical sciences ; patients ; Pediatrics ; Recurrence ; Retrospective Studies ; risk ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>The Journal of pediatrics, 2012-10, Vol.161 (4), p.671-675</ispartof><rights>Mosby, Inc.</rights><rights>2012 Mosby, Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-e643d1a058b7a654c3bfdf4638049f0d3cc45a1b267098fe6c60ab2872b799603</citedby><cites>FETCH-LOGICAL-c468t-e643d1a058b7a654c3bfdf4638049f0d3cc45a1b267098fe6c60ab2872b799603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26711854$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22575249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luca, Nadia Jennifer Chiara, MD</creatorcontrib><creatorcontrib>Lara-Corrales, Irene, MD, MSc</creatorcontrib><creatorcontrib>Pope, Elena, MD, MSc</creatorcontrib><title>Eczema Herpeticum in Children: Clinical Features and Factors Predictive of Hospitalization</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To describe the clinical characteristics of pediatric patients with eczema herpeticum and to determine the predictors of hospitalization, and recurrence and repeat episodes. Study design A retrospective cohort study of patients 0-18 years of age diagnosed with eczema herpeticum between May 2000 and April 2009 was carried out at a tertiary pediatric care center in Canada. Seventy-nine patients were included. The primary outcome was hospitalization; secondary outcomes were recurrent and repeat episodes of eczema herpeticum. Results At presentation, 76% of 79 patients with eczema herpeticum had a generalized eruption, 56% had fever, 37% had systemic symptoms, and 10% had eye involvement (keratoconjunctivitis). Forty-five patients (57%) were hospitalized. Predictors for hospitalization included male sex (OR = 3.09; 95% CI, 1.20-7.95, P = .017), fever (OR = 5.75; 95% CI, 2.17-15.26, P < .001), systemic symptoms (OR = 2.84; 95% CI, 1.06-7.62, P = .035), and age <1 year (OR = 7.17; 95% CI, 2.17-23.72, P = .001). Recurrence rate (<1 month) was 8.9% and rate of repeat episodes (>1 month) was 16%. Hospitalized patients were more likely to have a repeat episode (OR = 8.25; 95% CI, 0.99-68.69, P = .05). Patients with a previous history of eczema herpeticum had increased likelihood of early recurrence (OR = 6.80; 95% CI, 0.99-46.62, P = .05) and repeat episodes (OR = 9.43; 95% CI, 1.52-55.9, P = .01). Conclusions Predictors of hospitalization in this cohort included male sex, age <1 year, fever, and systemic symptoms at presentation. Hospitalized patients may be at risk for repeat episodes of eczema herpeticum.</description><subject>Acyclovir - therapeutic use</subject><subject>Adolescent</subject><subject>Algorithms</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bullous diseases of the skin</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>cohort studies</subject><subject>Dermatology</subject><subject>eczema</subject><subject>eyes</subject><subject>Female</subject><subject>fever</subject><subject>General aspects</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Kaposi Varicelliform Eruption - diagnosis</subject><subject>Kaposi Varicelliform Eruption - drug therapy</subject><subject>Kaposi Varicelliform Eruption - therapy</subject><subject>keratoconjunctivitis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>patients</subject><subject>Pediatrics</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>risk</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkk1r1UAUhoMo9rb6CwTNRugm8cxHZhJBQS69XqGgULtxM0wmJzoxyaQzSaH99U56rwpuXM3mec8ZnvckyQsCOQEi3nR5N2ETcgqE5sByKOSjZEOgkpkoGXucbAAozRiX4iQ5DaEDgIoDPE1OKC1kQXm1Sb5dmHscdLpHP-FszTKkdky3P2zfeBzfptvejtboPt2hnhePIdVjk-60mZ0P6RePjTWzvcXUtenehcnOurf3erZufJY8aXUf8PnxPUuudxdft_vs8vPHT9sPl5nhopwzFJw1RENR1lKLghtWt03LBSuBVy00zBheaFJTIaEqWxRGgK5pKWktq0oAO0vOD3Mn724WDLMabDDY93pEtwRFQEYFhSQ8ouyAGu9C8NiqydtB-7sIqVWq6tSDVLVKVcBUlBpTL48LlnrA5k_mt8UIvD4COkRXrdejseEvJyQhZbGuf3XgWu2U_u4jc30VNxWxmVKKh0nvDgRGYbcWvQrG4miiZo9mVo2z__nq-3_y5ljgT7zD0LnFj7ELRVSIGXW1Xsh6IIQCMCEE-wVySLOG</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Luca, Nadia Jennifer Chiara, MD</creator><creator>Lara-Corrales, Irene, MD, MSc</creator><creator>Pope, Elena, MD, MSc</creator><general>Elsevier Inc</general><general>Mosby, Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Eczema Herpeticum in Children: Clinical Features and Factors Predictive of Hospitalization</title><author>Luca, Nadia Jennifer Chiara, MD ; Lara-Corrales, Irene, MD, MSc ; Pope, Elena, MD, MSc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-e643d1a058b7a654c3bfdf4638049f0d3cc45a1b267098fe6c60ab2872b799603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acyclovir - therapeutic use</topic><topic>Adolescent</topic><topic>Algorithms</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bullous diseases of the skin</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>cohort studies</topic><topic>Dermatology</topic><topic>eczema</topic><topic>eyes</topic><topic>Female</topic><topic>fever</topic><topic>General aspects</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Kaposi Varicelliform Eruption - diagnosis</topic><topic>Kaposi Varicelliform Eruption - drug therapy</topic><topic>Kaposi Varicelliform Eruption - therapy</topic><topic>keratoconjunctivitis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>patients</topic><topic>Pediatrics</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>risk</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luca, Nadia Jennifer Chiara, MD</creatorcontrib><creatorcontrib>Lara-Corrales, Irene, MD, MSc</creatorcontrib><creatorcontrib>Pope, Elena, MD, MSc</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luca, Nadia Jennifer Chiara, MD</au><au>Lara-Corrales, Irene, MD, MSc</au><au>Pope, Elena, MD, MSc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eczema Herpeticum in Children: Clinical Features and Factors Predictive of Hospitalization</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>161</volume><issue>4</issue><spage>671</spage><epage>675</epage><pages>671-675</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective To describe the clinical characteristics of pediatric patients with eczema herpeticum and to determine the predictors of hospitalization, and recurrence and repeat episodes. Study design A retrospective cohort study of patients 0-18 years of age diagnosed with eczema herpeticum between May 2000 and April 2009 was carried out at a tertiary pediatric care center in Canada. Seventy-nine patients were included. The primary outcome was hospitalization; secondary outcomes were recurrent and repeat episodes of eczema herpeticum. Results At presentation, 76% of 79 patients with eczema herpeticum had a generalized eruption, 56% had fever, 37% had systemic symptoms, and 10% had eye involvement (keratoconjunctivitis). Forty-five patients (57%) were hospitalized. Predictors for hospitalization included male sex (OR = 3.09; 95% CI, 1.20-7.95, P = .017), fever (OR = 5.75; 95% CI, 2.17-15.26, P < .001), systemic symptoms (OR = 2.84; 95% CI, 1.06-7.62, P = .035), and age <1 year (OR = 7.17; 95% CI, 2.17-23.72, P = .001). Recurrence rate (<1 month) was 8.9% and rate of repeat episodes (>1 month) was 16%. Hospitalized patients were more likely to have a repeat episode (OR = 8.25; 95% CI, 0.99-68.69, P = .05). Patients with a previous history of eczema herpeticum had increased likelihood of early recurrence (OR = 6.80; 95% CI, 0.99-46.62, P = .05) and repeat episodes (OR = 9.43; 95% CI, 1.52-55.9, P = .01). Conclusions Predictors of hospitalization in this cohort included male sex, age <1 year, fever, and systemic symptoms at presentation. Hospitalized patients may be at risk for repeat episodes of eczema herpeticum.</abstract><cop>Maryland Heights, MO</cop><pub>Elsevier Inc</pub><pmid>22575249</pmid><doi>10.1016/j.jpeds.2012.03.057</doi><tpages>5</tpages></addata></record> |
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| subjects | Acyclovir - therapeutic use Adolescent Algorithms Antiviral Agents - therapeutic use Biological and medical sciences Bullous diseases of the skin Child Child, Preschool children cohort studies Dermatology eczema eyes Female fever General aspects Hospitalization - statistics & numerical data Human viral diseases Humans Infant Infectious diseases Kaposi Varicelliform Eruption - diagnosis Kaposi Varicelliform Eruption - drug therapy Kaposi Varicelliform Eruption - therapy keratoconjunctivitis Male Medical sciences patients Pediatrics Recurrence Retrospective Studies risk Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | Eczema Herpeticum in Children: Clinical Features and Factors Predictive of Hospitalization |
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