Estimating the Genetic Variance of Major Depressive Disorder Due to All Single Nucleotide Polymorphisms

Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-wide association studies of major depressive disorder in particular have so far been unsuccessful in...

Full description

Saved in:
Bibliographic Details
Published in:Biological psychiatry (1969) 2012-10, Vol.72 (8), p.707-709
Main Authors: Lubke, Gitta H, Hottenga, Jouke Jan, Walters, Raymond, Laurin, Charles, de Geus, Eco J.C, Willemsen, Gonneke, Smit, Jan H, Middeldorp, Christel M, Penninx, Brenda W.J.H, Vink, Jacqueline M, Boomsma, Dorret I
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult and adolescent clinical studies
Biological and medical sciences
Depression
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - genetics
Fasting
Fasting glucose
Female
Genetic Predisposition to Disease
Genetic Variation - genetics
genome-wide association studies (GWAS)
Genome-Wide Association Study
genome-wide complex trait analysis (GCTA)
Genotype
Glucose
height
Humans
major depressive disorder (MDD)
Male
Medical sciences
missing heritability
Models, Statistical
Mood disorders
Netherlands
Polymorphism, Single Nucleotide - genetics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
smoking
Smoking - genetics
Tobacco smoking
Tobacco, tobacco smoking
Toxicology
Twin Studies as Topic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-wide association studies of major depressive disorder in particular have so far been unsuccessful in detecting genome-wide significant single nucleotide polymorphisms (SNPs). Using two recently proposed methods designed to estimate the heritability of a phenotype that is attributable to genome-wide SNPs, we show that SNPs on current platforms contain substantial information concerning the additive genetic variance of major depressive disorder. To assess the consistency of these two methods, we analyzed four other complex phenotypes from different domains. The pattern of results is consistent with estimates of heritability obtained in twin studies carried out in the same population.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2012.03.011