Negative effects of ultrafine particle exposure during forced exercise on the expression of Brain-Derived Neurotrophic Factor in the hippocampus of rats

Highlights ► We exposed 4 groups of rats to exercise or rest in ambient air or UFP-polluted air. ► Gene expression in hippocampus, prefrontal cortex and olfactory bulb was analyzed. ► Exercise in ambient air increased hippocampal BDNF expression. ► Hippocampal BDNF expression did not increase follow...

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Bibliographic Details
Published in:Neuroscience 2012-10, Vol.223, p.131-139
Main Authors: Bos, I, De Boever, P, Int Panis, L, Sarre, S, Meeusen, R
Format: Article
Language:English
Subjects:
air pollution
Animals
BDNF
Biological and medical sciences
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Cytokines - genetics
Cytokines - metabolism
exercise
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Gene Expression Regulation - physiology
Hippocampus - drug effects
Hippocampus - metabolism
Male
Neurology
Nitric Oxide Synthase Type I - genetics
Nitric Oxide Synthase Type I - metabolism
Nitric Oxide Synthase Type II - genetics
Nitric Oxide Synthase Type II - metabolism
olfactory bulb
Olfactory system and olfaction. Gustatory system and gustation
particulate matter
Physical Conditioning, Animal
prefrontal cortex
Rats
Rats, Wistar
RNA, Messenger - metabolism
Silicones - pharmacology
Vertebrates: nervous system and sense organs
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Summary:Highlights ► We exposed 4 groups of rats to exercise or rest in ambient air or UFP-polluted air. ► Gene expression in hippocampus, prefrontal cortex and olfactory bulb was analyzed. ► Exercise in ambient air increased hippocampal BDNF expression. ► Hippocampal BDNF expression did not increase following exercise in UFP-polluted air.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.07.057