Chronic Kidney Disease in Patients with Ischemic Stroke

• Published in: Journal of stroke and cerebrovascular diseases 2012-10, Vol.21 (7), p.547-550
• Main Authors: Tsukamoto, Yuuko, MD, Takahashi, Wakoh, MD, Takizawa, Shunya, MD, Kawada, Shiaki, MD, Takagi, Shigeharu, MD
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biomarkers - blood; brain infarction; Brain Infarction - diagnosis; Brain Infarction - epidemiology; Brain Ischemia - diagnosis; Brain Ischemia - epidemiology; Cardiovascular; Case-Control Studies; cerebrovascular risk factor; Chi-Square Distribution; Creatinine - blood; Female; Glomerular Filtration Rate; Humans; Japan - epidemiology; Kidney - physiopathology; Logistic Models; Male; Middle Aged; Neurology; Odds Ratio; Prevalence; Prognosis; Renal dysfunction; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - physiopathology; Risk Assessment; Risk Factors; Severity of Illness Index
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2010.12.005

To examine the significance of renal dysfunction in patients who have sustained ischemic stroke, we examined the relationship between the renal function evaluated in terms of estimated glomerular filtration rate (eGFR) and the subtype of brain infarction (BI) in patients with ischemic stroke. A total of 639 patients with BI were enrolled in this study, with 314 subjects without stroke or transient ischemic attack registered as age-matched controls. eGFR was calculated according to the equation 194 × Cr−1.094 × Age−0.287 (−0.739 if female), where Cr is serum creatinine concentration, and was classified into four stages: stage I, eGFR ≥90 mL/min/1.73 m2 ; stage II, eGFR 60∼89 mL/min/1.73 m2 ; stage III, eGFR 30∼59 mL/min/1.73 m2 ; and stage IV, eGFR