Co-inheritance of variants/mutations in Malaysian patients with Crohn's disease

Crohn's disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohn's disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms t...

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Bibliographic Details
Published in:Genetics and molecular research 2012-01, Vol.11 (3), p.3115-3121
Main Authors: Chua, K H, Ng, C C, Hilmi, I, Goh, K L
Format: Article
Language:English
Subjects:
5' Untranslated Regions - genetics
Base Sequence
Crohn Disease - genetics
DNA Mutational Analysis
Exons - genetics
Genetic Variation
Humans
Inheritance Patterns - genetics
Integrin alphaV - genetics
Malaysia
Molecular Sequence Data
Mutation - genetics
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Summary:Crohn's disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohn's disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms that could influence Crohn's disease development. Based on the sequencing results, a homozygous 5'-UTR-59 G to A variant in exon 1 (SNP6) was observed in a patient who carried SNP5, while a heterozygous SNP6 variant was detected in the other patient who carried SNP5. No other associated mutations or polymorphisms were detected in the two patients who carried the JW1 variant of the CARD15/NOD2 gene.
ISSN:1676-5680
1676-5680
DOI:10.4238/2012.August.31.9