Advanced Left Ventricular Diastolic Dysfunction in Uremic Patients With Type 2 Diabetes on Maintenance Hemodialysis

Background: Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Myocardial dysfunction may occur in patients with diabetes mellitus (DM) in the absence of coronary artery disease or left ventricular (LV) hypertrophy. Although tissue Doppler imaging (TDI) is a highly effectiv...

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Bibliographic Details
Published in:Circulation Journal 2012, Vol.76(10), pp.2380-2385
Main Authors: Hung, Kuo-Chun, Lee, Cheng-Hung, Chen, Chun-Chi, Chu, Chi-Ming, Wang, Chao-Yung, Hsieh, I-Chang, Fang, Ji-Tseng, Lin, Fen-Chiung, Wen, Ming-Shien
Format: Article
Language:English
Subjects:
Adult
Aged
Diabetes mellitus
Diabetes Mellitus, Type 2 - diagnostic imaging
Diabetes Mellitus, Type 2 - physiopathology
Diabetes Mellitus, Type 2 - therapy
Diabetic Nephropathies - diagnostic imaging
Diabetic Nephropathies - physiopathology
Diabetic Nephropathies - therapy
Diastole
Echocardiography, Doppler
End-stage renal disease
Female
Heart Atria - diagnostic imaging
Heart Atria - physiopathology
Humans
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - therapy
Male
Middle Aged
Renal Dialysis
Tissue Doppler imaging
Uremia - diagnostic imaging
Uremia - etiology
Uremia - physiopathology
Uremia - therapy
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Left - therapy
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Summary:Background: Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Myocardial dysfunction may occur in patients with diabetes mellitus (DM) in the absence of coronary artery disease or left ventricular (LV) hypertrophy. Although tissue Doppler imaging (TDI) is a highly effective means of quantifying myocardial diastolic function, its differences in ESRD patients with diabetes and without diabetes remain unclear. Methods and Results: A total of 101 ESRD patients on maintenance hemodialysis with normal LV systolic function were studied: 37 with type 2 DM and 64 without DM. Conventional echocardiography and TDI were performed to evaluate LV systolic and diastolic functions. The conventional LV systolic and diastolic echocardiographic parameters did not differ according to presence of DM, except for the left atrial size and volume index (P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-12-0471