Near-Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetics

A molecular nanoprobe: Glutathione‐coated near‐infrared‐emitting radioactive gold nanoparticles have been synthezised and behave like small‐molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half‐life, a desirable elimination half‐life, and hold promise for s...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-10, Vol.51 (40), p.10118-10122
Main Authors: Zhou, Chen, Hao, Guiyang, Thomas, Patrick, Liu, Jinbin, Yu, Mengxiao, Sun, Shasha, Öz, Orhan K., Sun, Xiankai, Zheng, Jie
Format: Article
Language:English
Subjects:
Chromatography, High Pressure Liquid
gold
Gold - chemistry
imaging agents
Luminescence
Metal Nanoparticles - chemistry
Molecular Probes - chemical synthesis
Molecular Probes - chemistry
nanoparticles
Pharmacokinetics
Spectroscopy, Near-Infrared
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Summary:A molecular nanoprobe: Glutathione‐coated near‐infrared‐emitting radioactive gold nanoparticles have been synthezised and behave like small‐molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half‐life, a desirable elimination half‐life, and hold promise for single‐photon emission computed tomography (SPECT) and fluorescence imaging (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203031