Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand White rabbits

The present study examined the protective effects of taurine on alloxan-induced diabetic cataracts and lens damage in male New Zealand White rabbits. The animals were randomly divided into three treatment groups: (1) normal control (vehicle administration); (2) diabetes (100 mg/kg alloxan administra...

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Bibliographic Details
Published in:Experimental eye research 2012-10, Vol.103, p.71-77
Main Authors: Hsu, Yu-Wen, Yeh, Shang-Min, Chen, Ya-Yu, Chen, Yi-Chen, Lin, Shiun-Long, Tseng, Jung-Kai
Format: Article
Language:English
Subjects:
Alloxan
Animals
Blood Glucose - metabolism
Body Weight - drug effects
cataract
Cataract - chemically induced
Cataract - pathology
Cataract - prevention & control
diabetes
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - pathology
Diabetes Mellitus, Experimental - prevention & control
Hyperglycemia - chemically induced
Hyperglycemia - diagnosis
Hyperglycemia - prevention & control
Hyperopia - chemically induced
Hyperopia - diagnosis
Hyperopia - prevention & control
lens
Male
Rabbits
Refraction, Ocular - drug effects
Retinoscopy
taurine
Taurine - pharmacology
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Summary:The present study examined the protective effects of taurine on alloxan-induced diabetic cataracts and lens damage in male New Zealand White rabbits. The animals were randomly divided into three treatment groups: (1) normal control (vehicle administration); (2) diabetes (100 mg/kg alloxan administration); and (3) diabetes + taurine (1% [w/v] taurine dissolved in drinking water and alloxan administration). The results showed that alloxan-induced diabetes caused significant (p 
ISSN:0014-4835
1096-0007
DOI:10.1016/j.exer.2012.08.001