Monitoring in vitro thrombus formation with novel microfluidic devices

Cardiovascular disease is a major cause of mortality globally and is subject to ongoing research to improve clinical treatment. It is established that activation of platelets and coagulation are central to thrombosis, yet at different extents in the arterial and venous system. In vitro perfusion cha...

Full description

Saved in:
Bibliographic Details
Published in:Platelets (Edinburgh) 2012-11, Vol.23 (7), p.501-509
Main Authors: Westein, Erik, de Witt, Susanne, Lamers, Moniek, Cosemans, Judith M.E.M., Heemskerk, Johan W.M.
Format: Article
Language:English
Subjects:
Blood Coagulation
Blood Platelets - physiology
Cells, Cultured
Hemorheology
Humans
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Microfluidics
Platelet Activation
Platelet Aggregation
Platelet Function Tests
real time thrombus formation
Thrombosis - blood
Thrombosis - diagnosis
Thrombosis - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular disease is a major cause of mortality globally and is subject to ongoing research to improve clinical treatment. It is established that activation of platelets and coagulation are central to thrombosis, yet at different extents in the arterial and venous system. In vitro perfusion chamber technology has contributed significant knowledge on the function of platelets in the thrombotic process under shear conditions. Recent efforts to downscale this technique with a variety of microfluidic devices has opened new possibilities to study this process under precisely controlled flow conditions. Such microfluidic devices possess the capability to execute platelet function tests more quickly than current assays, while using small blood samples. Gradually becoming available to the clinic now, they may provide a new means to manage the treatment of cardiovascular diseases, although accurate validation studies still are missing. This review highlights the progress that has been made in monitoring aspects of thrombus formation using microfluidic devices.
ISSN:0953-7104
1369-1635
DOI:10.3109/09537104.2012.709653