Development of a potentiometric mefenamate ion sensor for the determination of mefenamic acid in pharmaceuticals and human blood serum

The characteristics, performance, and application of a novel and simple electrode, namely Pt|Hg|Hg 2(MF) 2|Graphite, where MF stands for mefenamate ion, are described. This electrode responds to MF with sensitivity of (58.9 ± 0.7) mV decade −1 over the range 1.0 × 10 −6 to 1.0 × 10 −2 mol L −1 at pH...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2007-12, Vol.128 (1), p.117-123
Main Authors: Santini, A.O., Pezza, H.R., Pezza, L.
Format: Article
Language:English
Subjects:
Actuators
Blood
Electrodes
Human
Human blood serum
Mefenamate-sensitive electrode
Pharmaceuticals
Potentiometry
Sensors
Serums
Stands
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Summary:The characteristics, performance, and application of a novel and simple electrode, namely Pt|Hg|Hg 2(MF) 2|Graphite, where MF stands for mefenamate ion, are described. This electrode responds to MF with sensitivity of (58.9 ± 0.7) mV decade −1 over the range 1.0 × 10 −6 to 1.0 × 10 −2 mol L −1 at pH 6.0–9.0 and a detection limit of 6.2 × 10 −7 mol L −1. The electrode is easily constructed at a relatively low cost with fast response time (within 10–25 s) and can be used for a period of 4 months without significant change in its performance characteristics. The proposed sensor displayed good selectivity for mefenamate in the presence of several substances, especially concerning carboxylate and inorganic anions. The potentiometric sensor was successfully applied to the determination of mefenamic acid in pharmaceuticals and human serum samples.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2007.05.039