Biomimetic formation of crystalline bone-like apatite layers on spongy materials templated by bile salts aggregates

• Published in: Journal of materials science 2012-03, Vol.47 (6), p.2837-2844
• Main Authors: Fernández-Leyes, Marcos, Verdinelli, Valeria, Hassan, Natalia, Ruso, Juan M., Pieroni, Olga, Schulz, Pablo C., Messina, Paula
• Format: Article
• Language: English
• Subjects: Aggregates; Apatite; Bile; Biocompatibility; Biomedical materials; Biomimetic materials; Body fluids; Bones; Characterization and Evaluation of Materials; Chemistry and Materials Science; Classical Mechanics; Contact; Correlation; Crystal structure; Crystallography and Scattering Methods; In vitro methods and tests; Materials Science; Morphology; Phosphate minerals; Phosphate rock; Polymer Sciences; Porosity; Silica; Silicon dioxide; Sol-gel processes; Solid Mechanics; Surgical implants; Synthesis
• ISSN: 0022-2461; 1573-4803
• DOI: 10.1007/s10853-011-6113-4

Since the trabecular bone exhibit sponge-like bicontinuity there is a growing interest in the synthesis of spongy-like sieves for the construction of bio-active implantable materials. Here, we propose a one step sol–gel method for the synthesis of bicontinuous pore silica materials using different bile salts aqueous mixtures as templates. The influences of the type and amount of bile salt on the synthesis processes are investigated and correlated with the final material morphology. As a final point, their structural properties are interrelated with their ability to induce a bone-like apatite layer in contact with simulated body fluid (SBF). We have confirmed that under specific template conditions, the synthesized material has an open bio-active macropore structure that is blanched in a 3D-disordered sponge-like network similar than those existed in trabecular bone.