The small heat shock proteins family: The long forgotten chaperones

Small heat shock proteins are a rather heterogeneous family of ATP-independent chaperones, some of which have been proven to block protein aggregation and help the cells to survive stressful conditions. Although much less studied than high molecular weight HSPs like HSP70/HSPA or HSP90/HSPC, their i...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2012-10, Vol.44 (10), p.1588-1592
Main Authors: Garrido, C., Paul, C., Seigneuric, R., Kampinga, H.H.
Format: Article
Language:English
Subjects:
Agglomeration
Apoptosis Regulatory Proteins - metabolism
Biochemistry
Biology
Blocking
cell biology
Chaperone
Chaperonopathies
Cytoskeleton - metabolism
Heat shock proteins
Heat-Shock Proteins, Small - genetics
Heat-Shock Proteins, Small - metabolism
Heat-Shock Proteins, Small - physiology
Hereditary Sensory and Autonomic Neuropathies - genetics
HSPB
Human
human diseases
Humans
Molecular weight
Muscular Diseases - genetics
Mutation
Oxidative Stress
Pathology
physiology
Protein Folding
Protein Processing, Post-Translational
Small Heat Shock Protein
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Summary:Small heat shock proteins are a rather heterogeneous family of ATP-independent chaperones, some of which have been proven to block protein aggregation and help the cells to survive stressful conditions. Although much less studied than high molecular weight HSPs like HSP70/HSPA or HSP90/HSPC, their implication in physio-pathological processes and human diseases is now well evidenced, as it will be discussed in the different reviews of this special issue. In this mini-review we will just present a general introduction about the small heat shock proteins family. This article is part of a Directed Issue entitled: Small HSPs in physiology and pathology.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2012.02.022