Loading…

A randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery

Summary Deep neuromuscular blockade during certain surgical procedures may improve operating conditions. Sugammadex can be used to reverse deep neuromuscular blockade without waiting for spontaneous recovery. This randomised study compared recovery times from neuromuscular blockade induced by rocuro...

Full description

Saved in:
Bibliographic Details
Published in:Anaesthesia 2012-09, Vol.67 (9), p.991-998
Main Authors: Geldner, G., Niskanen, M., Laurila, P., Mizikov, V., Hübler, M., Beck, G., Rietbergen, H., Nicolayenko, E.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Deep neuromuscular blockade during certain surgical procedures may improve operating conditions. Sugammadex can be used to reverse deep neuromuscular blockade without waiting for spontaneous recovery. This randomised study compared recovery times from neuromuscular blockade induced by rocuronium 0.6 mg.kg−1, using sugammadex 4 mg.kg−1 administered at 1–2 post‐tetanic count (deep blockade) or neostigmine 50 μg.kg−1 (plus atropine 10 μg.kg−1) administered at the re‐appearance of the second twitch of a train‐of‐four stimulation (moderate blockade), in patients undergoing laparoscopic surgery. The primary efficacy variable was the time from the start of sugammadex/neostigmine administration to recovery of the train‐of‐four ratio to 0.9. Patients receiving sugammadex recovered 3.4 times faster than patients receiving neostigmine (geometric mean (95% CI) recovery times of 2.4 (2.1–2.7) and 8.4 (7.2–9.8) min, respectively, p 
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.2012.07197.x