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A randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery
Summary Deep neuromuscular blockade during certain surgical procedures may improve operating conditions. Sugammadex can be used to reverse deep neuromuscular blockade without waiting for spontaneous recovery. This randomised study compared recovery times from neuromuscular blockade induced by rocuro...
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Published in: | Anaesthesia 2012-09, Vol.67 (9), p.991-998 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Summary
Deep neuromuscular blockade during certain surgical procedures may improve operating conditions. Sugammadex can be used to reverse deep neuromuscular blockade without waiting for spontaneous recovery. This randomised study compared recovery times from neuromuscular blockade induced by rocuronium 0.6 mg.kg−1, using sugammadex 4 mg.kg−1 administered at 1–2 post‐tetanic count (deep blockade) or neostigmine 50 μg.kg−1 (plus atropine 10 μg.kg−1) administered at the re‐appearance of the second twitch of a train‐of‐four stimulation (moderate blockade), in patients undergoing laparoscopic surgery. The primary efficacy variable was the time from the start of sugammadex/neostigmine administration to recovery of the train‐of‐four ratio to 0.9. Patients receiving sugammadex recovered 3.4 times faster than patients receiving neostigmine (geometric mean (95% CI) recovery times of 2.4 (2.1–2.7) and 8.4 (7.2–9.8) min, respectively, p |
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ISSN: | 0003-2409 1365-2044 |
DOI: | 10.1111/j.1365-2044.2012.07197.x |